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dc.contributor.authorIravani, Mahmoud M.
dc.contributor.authorMillar, J.
dc.contributor.authorKruk, Z. L.
dc.date.accessioned2014-01-22T15:30:28Z
dc.date.available2014-01-22T15:30:28Z
dc.date.issued1998-11
dc.identifier.citationIravani , M M , Millar , J & Kruk , Z L 1998 , ' Differential release of dopamine by nitric oxide in subregions of rat caudate putamen slices ' , Journal of Neurochemistry , vol. 71 , no. 5 , pp. 1969-1977 . https://doi.org/10.1046/j.1471-4159.1998.71051969.x
dc.identifier.issn0022-3042
dc.identifier.otherPURE: 736069
dc.identifier.otherPURE UUID: 57e8ac76-6393-454e-b7a2-213087188a84
dc.identifier.otherWOS: 000076576100019
dc.identifier.otherScopus: 0031753793
dc.identifier.otherORCID: /0000-0002-4905-9682/work/32997605
dc.identifier.urihttp://hdl.handle.net/2299/12619
dc.description.abstractFast cyclic voltammetry was used to measure NO and dopamine (DA) simultaneously in rat caudate putamen (CPu) slices. Analysis of electrochemical signals obtained from mixtures of DA and NO showed that subtraction of either the DA or the NO component revealed the contribution of the other component. Application of such data manipulation to signals obtained in CPu slices indicated that DA and NO components contributed to electrochemical signals. Following electrical stimulation (>1 s), site-dependent NO-like signals were observed. Pressure ejection of NMDA yielded a biphasic electrochemical signal. The first phase (lasting 10-20 s) had electrochemical characteristics of DA and was observed only during the first application of NMDA, The second phase developed more slowly, was of longer duration (1-3 min), and had electrochemical characteristics of a mixture of DA and NO. Generation of the NO-like signal by NMDA was antagonised by L-N-monomethylarginine. Pressure ejection of NO into CPu slices caused dose- and site-dependent DA release. More DA was released in the dorsolateral than in the dorsomedial CPu. Pressure ejection of DA did not generate NO. It is concluded that electrically stimulated DA release is not mediated by prior release of NO.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofJournal of Neurochemistry
dc.subjectbrain slice
dc.subjectcaudate putamen
dc.subjectcerebellum
dc.subjectdopamine
dc.subjectelectrochemistry
dc.subjectelectrical stimulation
dc.subjectnitric oxide
dc.subjectN-methyl-D-aspartate
dc.subjectpressure ejection
dc.subjectvoltammetry
dc.subjectFAST CYCLIC VOLTAMMETRY
dc.subjectSTRIATUM IN-VITRO
dc.subjectSYNTHASE ACTIVITY
dc.subjectBASAL GANGLIA
dc.subjectBRAIN SLICES
dc.subjectH-3 DOPAMINE
dc.subjectARGININE
dc.subjectCALCIUM
dc.subjectVIVO
dc.subjectMICROSENSOR
dc.titleDifferential release of dopamine by nitric oxide in subregions of rat caudate putamen slicesen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionNeurodegenerative Diseases
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted1998-11
rioxxterms.versionofrecordhttps://doi.org/10.1046/j.1471-4159.1998.71051969.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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