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dc.contributor.authorShetage, Satyajit
dc.contributor.authorTraynor, M.J.
dc.contributor.authorBrown, Marc
dc.contributor.authorRaji, Mahad
dc.contributor.authorGraham-Kalio, Diepiriyie
dc.contributor.authorChilcott, Robert
dc.date.accessioned2014-01-22T16:00:30Z
dc.date.available2014-01-22T16:00:30Z
dc.date.issued2014-02
dc.identifier.citationShetage , S , Traynor , M J , Brown , M , Raji , M , Graham-Kalio , D & Chilcott , R 2014 , ' Effect of ethnicity, gender and age on the amount and composition of residual skin surface components derived from sebum, sweat and epidermal lipids ' , Skin Research and Technology , vol. 20 , no. 1 , pp. 97-107 . https://doi.org/10.1111/srt.12091
dc.identifier.issn0909-752X
dc.identifier.otherPURE: 2027557
dc.identifier.otherPURE UUID: f0038982-88d6-4972-bf1a-19379d2a4abe
dc.identifier.otherScopus: 84892368962
dc.identifier.urihttp://hdl.handle.net/2299/12624
dc.description© 2013 The Authors. Skin Research and Technology published by John Wiley & Sons Ltd This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes
dc.description.abstractBackground/purpose: The superficial layer on the skin surface, known as the acid mantle, comprises a mixture of sebum, sweat, corneocyte debris and constituents of natural moisturizing factor. Thus, the phrase 'residual skin surface components' (RSSC) is an appropriate term for the mixture of substances recovered from the skin surface. There is no general agreement about the effects of ethnicity, gender and age on RSSC. The aim of this human volunteer study was to evaluate RSSC in relation to ethnicity, gender and age. A suitable acquisition medium for RSSC collection was identified and samples of RSSC were subsequently analysed using gas chromatography-mass spectrometry (GC-MS) and gravimetry. Methods: A total of 315 volunteers participated in the study from a range of self-declared ethnic backgrounds. Six acquisition media were compared to determine the most suitable media for RSSC collection. The effect of age, gender and ethnicity on RSSC collection was evaluated by gravimetric analysis while GC-MS was used to determine the composition of RSSC. Results: Of the six candidate materials assessed, cigarette paper provided the most practical and reproducible sample acquisition medium. There was no significant difference in the amount of RSSC collected when based on gender and ethnicity and no significant correlation between RSSC recovery and age. Up to 49 compounds were detected from human RSSC when analysed by GC-MS. Conclusions: The results of the present study suggest that RSSC can be effectively collected using cigarette paper and analysed by GC-MS. Ethnicity, gender and age had no significant impact on the quantity of RSSC recovered from the skin surface.en
dc.format.extent11
dc.language.isoeng
dc.relation.ispartofSkin Research and Technology
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.subjectsebum
dc.subjectskin surface lipids
dc.subjectcigarette paper
dc.subjectethnicity
dc.subjectgender
dc.subjectage
dc.subjectgas chromatography-mass spectrometry
dc.titleEffect of ethnicity, gender and age on the amount and composition of residual skin surface components derived from sebum, sweat and epidermal lipidsen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionToxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionNanopharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1111/srt.12091
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeopenAccess


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