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dc.contributor.authorIravani, Mahmoud M.
dc.contributor.authorKruk, Z. L.
dc.date.accessioned2014-01-23T12:00:32Z
dc.date.available2014-01-23T12:00:32Z
dc.date.issued1997-01
dc.identifier.citationIravani , M M & Kruk , Z L 1997 , ' Real-time measurement of stimulated 5-hydroxytryptamine release in rat substantia nigra pars reticulata brain slices ' , Synapse: journal & newsletter of the Association of Chartered Physiotherapists Interested in Neurology , vol. 25 , no. 1 , pp. 93-102 . https://doi.org/10.1002/(SICI)1098-2396(199701)25:1<93::AID-SYN11>3.0.CO;2-#
dc.identifier.issn0887-4476
dc.identifier.otherPURE: 736117
dc.identifier.otherPURE UUID: 1c691318-0e53-4b34-a45d-3f04e20c2684
dc.identifier.otherWOS: A1997VZ86600011
dc.identifier.otherScopus: 0031021895
dc.identifier.urihttp://hdl.handle.net/2299/12641
dc.description.abstractFast cyclic voltammetry at a carbon fibre microelectrode was used to measure 5-HT signals following electrical or chemical stimulation in rat substantia nigra pars reticulata slices. Chemical stimulation with (+)-amphetamine or veratrine gave signals which were indistinguishable from those of exogenous 5-HT Electrical stimulation of sufficient duration gave voltammetric signals which were characteristic of 5-HT. Release of dopamine was not detected following either chemical or electrical stimulation. The 5-HT signals were attenuated by TTX and enhanced by fluvoxamine. It was not possible to demonstrate regulation of 5-HT release in the SNr by 5-HT1B autoreceptors using CGS 12066A or methiothepin. Signal following electrical stimulation were not enhanced by either benztropine or GBR12909, or modified in the presence of either quinpirole or sulpiride. We conclude that 5-HT release can be detected voltammetrically in the SNr; 5-HT release is likely to be from axon terminals, but somatodendritic DA release could not be detected. (C) 1997 Wiley-Liss, Inc.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofSynapse: journal & newsletter of the Association of Chartered Physiotherapists Interested in Neurology
dc.subjectsubstantia nigra pars reticulata
dc.subjectfast cyclic voltammetry
dc.subjectcarbon fibre electrodes
dc.subjectelectrical stimulation
dc.subjectchemical stimulation
dc.subject5-hydroxytryptamine
dc.subjectaxonal release
dc.subjectFAST CYCLIC VOLTAMMETRY
dc.subjectVENTRAL TEGMENTAL AREA
dc.subjectTERMINAL 5-HT AUTORECEPTORS
dc.subjectGUINEA-PIG BRAIN
dc.subjectDOPAMINE RELEASE
dc.subjectDORSAL RAPHE
dc.subjectIN-VITRO
dc.subjectNUCLEUS-ACCUMBENS
dc.subjectBINDING-SITES
dc.subjectSUPRACHIASMATIC NUCLEUS
dc.titleReal-time measurement of stimulated 5-hydroxytryptamine release in rat substantia nigra pars reticulata brain slicesen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionNeurodegenerative Diseases
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted1997-01
rioxxterms.versionofrecordhttps://doi.org/10.1002/(SICI)1098-2396(199701)25:1<93::AID-SYN11>3.0.CO;2-#
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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