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dc.contributor.authorMcAuley, William James
dc.contributor.authorKravitz, Laura
dc.identifier.citationMcAuley , W J & Kravitz , L 2012 , ' Pharmacokinetics of topical products ' , Dermatological Nursing , vol. 11 , no. 2 , pp. 40-44 .
dc.identifier.otherPURE: 1285534
dc.identifier.otherPURE UUID: eaf376de-eec0-4abf-8982-f1839b9e2094
dc.description.abstractPharmacokinetics is the study of changes in drug concentrations in the body with time. It is commonly considered in four main phases: absorption, distribution, metabolism and excretion. Following topical administration, drugs must first be absorbed into the skin, from where they distribute through the skin tissue. Drug metabolism may occur in the skin but once the drug reaches the systemic circulation, its fate is similar to that of systemically administered drugs. The concentrations of a drug that reach the target site from a topically administered medicine are highly dependent on the characteristics of both the drug itself and its formulation, as well as the properties of the skin to which it is applied. This article in providing an overview of the topic discusses the general principles affecting drug pharmacokinetics and in particular drug absorption from topically applied formulationsen
dc.relation.ispartofDermatological Nursing
dc.titlePharmacokinetics of topical productsen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionCentre for Clinical Practice, Safe Medicines and Drug Misuse Research
dc.contributor.institutionPharmacy Education
dc.contributor.institutionLaw, Ethics and Professsionalism in Pharmacy Practice
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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