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dc.contributor.authorReimann, Manja
dc.contributor.authorDierkes, Jutta
dc.contributor.authorCarlsohn, Anja
dc.contributor.authorTalbot, Duncan
dc.contributor.authorFerrari, Marika
dc.contributor.authorHallund, Jesper
dc.contributor.authorHall, Wendy L
dc.contributor.authorVafeiadou, Katerina
dc.contributor.authorHuebner, Ulrich
dc.contributor.authorBranca, Francesco
dc.contributor.authorBugel, Susanne
dc.contributor.authorWilliams, Christine M
dc.contributor.authorZunft, H-J Franz
dc.contributor.authorKoebnick, Corinna
dc.date.accessioned2014-02-13T12:28:53Z
dc.date.available2014-02-13T12:28:53Z
dc.date.issued2006-01
dc.identifier.citationReimann , M , Dierkes , J , Carlsohn , A , Talbot , D , Ferrari , M , Hallund , J , Hall , W L , Vafeiadou , K , Huebner , U , Branca , F , Bugel , S , Williams , C M , Zunft , H-J F & Koebnick , C 2006 , ' Consumption of soy isoflavones does not affect plasma total homocysteine or asymmetric dimethylarginine concentrations in healthy postmenopausal women ' , Journal of Nutrition , vol. 136 , no. 1 , pp. 100-105 .
dc.identifier.issn0022-3166
dc.identifier.otherPURE: 2234693
dc.identifier.otherPURE UUID: 667ebbb1-8128-464b-9715-73c25ee789d4
dc.identifier.otherPubMed: 16365066
dc.identifier.otherScopus: 31544453293
dc.identifier.urihttp://hdl.handle.net/2299/12825
dc.description.abstractPostmenopausal women are at increased risk for cardiovascular disease because many risk factors are aggravated by menopause. Phytoestrogens may modulate risk factors favorably, involving mechanisms similar to estrogen. The effect of phytoestrogens on the atherogenic amino acids homocysteine and asymmetric dimethylarginine (ADMA) was investigated in a controlled intervention study in healthy postmenopausal women. A multicenter, double-blind, crossover intervention trial in 89 postmenopausal women from Denmark, Germany, and the UK was performed. Subjects consumed fruit cereal bars with or without soy isoflavones (50 mg/d) for 8 wk each with an 8-wk washout period in between. Urinary phytoestrogens increased significantly after isoflavone intervention (P <0.001). Isoflavone supplementation did not affect plasma total homocysteine or ADMA. For homocysteine, changes from baseline were 0.32 micromol/L (range: -0.31-0.92; 95% CI 0.13-0.72), and 0.29 micromol/L (range: -0.45-1.09; 95% CI 0.01-0.63, P = 0.286) for isoflavone treatment and placebo, respectively. For ADMA concentrations, changes from baseline were -0.02 micromol/L (range: -0.08-0.03; 95% CI -0.04-0.01, and 0.00 micromol/L (range: -0.05-0.03; 95% CI -0.03-0.01, P = 0.397) for isoflavone treatment and placebo, respectively. There was no association between plasma total homocysteine and ADMA. Changes from baseline in plasma ADMA and folate were negatively correlated (r = -0.18, P = 0.017). These results challenge the overall health effect of isoflavone supplementation in healthy postmenopausal women.en
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofJournal of Nutrition
dc.subjectAged
dc.subjectArginine
dc.subjectCholesterol
dc.subjectCross-Over Studies
dc.subjectDouble-Blind Method
dc.subjectFemale
dc.subjectGermany
dc.subjectHomocysteine
dc.subjectHumans
dc.subjectIsoflavones
dc.subjectMiddle Aged
dc.subjectPostmenopause
dc.subjectSoybean Proteins
dc.titleConsumption of soy isoflavones does not affect plasma total homocysteine or asymmetric dimethylarginine concentrations in healthy postmenopausal womenen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.contributor.institutionNutrition and Dietetics
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2006-01
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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