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dc.contributor.authorMcKellar, Quintin
dc.contributor.authorLees, P.
dc.contributor.authorGettinby, G.
dc.date.accessioned2014-03-11T09:58:56Z
dc.date.available2014-03-11T09:58:56Z
dc.date.issued1994-03-03
dc.identifier.citationMcKellar , Q , Lees , P & Gettinby , G 1994 , ' Pharmacodynamics of tolfenamic acid in dogs : Evaluation of dose response relationships ' , European Journal of Pharmacology , vol. 253 , no. 3 , pp. 191-200 . https://doi.org/10.1016/0014-2999(94)90191-0
dc.identifier.issn0014-2999
dc.identifier.otherPURE: 1443809
dc.identifier.otherPURE UUID: 1083b764-c25f-4786-9577-dd5eaaba7713
dc.identifier.otherPubMed: 8200415
dc.identifier.otherScopus: 0028326511
dc.identifier.urihttp://hdl.handle.net/2299/13075
dc.description.abstractTolfenamic acid was administered to beagle dogs at 2, 4 and 8 mg/kg bodyweight i.m. and the concentration of drug in plasma and in inflamed (administered carrageenan) and non-inflamed subcutaneous tissue cage fluid was measured. The concentration of thromboxane B2 in serum from blood allowed to clot under standardized conditions was determined and the concentrations of prostaglandin E2, 12-hydroxyeicosatetraenoic acid (12-HETE) and leucocyte numbers were measured in fluid from the carrageenan administered tissue cages. Skin temperature was also measured over each tissue cage following administration of drug. Tolfenamic acid displayed linear pharmacokinetics since the area under the plasma concentration time curve (AUC) values were 13.74 +/- 1.88, 29.82 +/- 6.53 and 50.52 +/- 5.73 micrograms/ml.h following administration of 2, 4 and 8 mg/kg, respectively. Tolfenamic acid proved to be a potent inhibitor of ex vivo thromboxane B2 generation in clotting blood. Maximal inhibition was greater than 80% at all dose rates and 97% at the 8 mg/kg dose rate 1 h after drug administration. It also proved to be a potent inhibitor of prostaglandin E2 production in inflammatory exudate, and significantly (P <0.05) decreased prostaglandin E2 production at all dose levels. Tolfenamic acid did not significantly alter 12-HETE generation or white blood cell accumulation in inflammatory exudate. Tolfenamic acid significantly reduced the elevated skin temperature over carrageenan administered cages at all dose levels.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Pharmacology
dc.titlePharmacodynamics of tolfenamic acid in dogs : Evaluation of dose response relationshipsen
dc.contributor.institutionOffice of the Vice-Chancellor
dc.contributor.institutionVeterinary Science
dc.contributor.institutionGeography, Environment and Agriculture
dc.description.statusPeer reviewed
dcterms.dateAccepted1994-03-03
rioxxterms.versionofrecordhttps://doi.org/10.1016/0014-2999(94)90191-0
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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