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dc.contributor.authorMcKellar, Quintin
dc.contributor.authorHarrison, P.
dc.contributor.authorGalbraith, E. A.
dc.contributor.authorInglis, H.
dc.date.accessioned2014-03-25T11:30:06Z
dc.date.available2014-03-25T11:30:06Z
dc.date.issued1990
dc.identifier.citationMcKellar , Q , Harrison , P , Galbraith , E A & Inglis , H 1990 , ' Pharmacokinetics of fenbendazole in dogs ' , Journal of Veterinary Pharmacology and Therapeutics , vol. 13 , no. 4 , pp. 386-92 . https://doi.org/10.1111/j.1365-2885.1990.tb00793.x
dc.identifier.issn0140-7783
dc.identifier.otherPURE: 1445098
dc.identifier.otherPURE UUID: df0c016b-ddce-4efe-91a7-5753a77c52b0
dc.identifier.otherPubMed: 2287030
dc.identifier.otherScopus: 0025655301
dc.identifier.urihttp://hdl.handle.net/2299/13183
dc.description.abstractFenbendazole was administered to dogs at a dose rate of 20 mg/kg body weight on a single occasion in gelatin capsules, on 5 consecutive days in feed, and on a single occasion as an alginate suspension. It was also administered at a dose rate of 100 mg/kg body weight on a single occasion in feed. Following single administration of 20 mg/kg fenbendazole mean maximum concentrations (Cmax) of the parent drug and its known active sulphoxide metabolite were 0.42 +/- 0.05 and 0.31 +/- 0.05 microgram/ml, respectively. Mean times until maximum concentrations were achieved (tmax) were 12.67 +/- 4.18 and 15.33 +/- 2.81 h, respectively, and areas under the plasma concentration-time curves (AUC) were 5.83 +/- 0.65 and 4.60 +/- 0.57 microgram.h/ml, respectively. Administration in feed increased the apparent bioavailability and administration for 5 consecutive days provided sustained plasma concentrations, generally greater than 0.2 microgram/ml. Administration as an alginate did not increase bioavailability or extend the persistence in plasma. It did increase the tmax to 16.80 +/- 2.93 and 20.00 +/- 2.53 h for fenbendazole and its sulphoxide metabolite, respectively. Increasing the dose from 20 mg/kg to 100 mg/kg did not substantially increase the Cmax or AUC.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.titlePharmacokinetics of fenbendazole in dogsen
dc.contributor.institutionOffice of the Vice-Chancellor
dc.contributor.institutionVeterinary Science
dc.contributor.institutionGeography, Environment and Agriculture
dc.description.statusPeer reviewed
dcterms.dateAccepted1990
rioxxterms.versionofrecordhttps://doi.org/10.1111/j.1365-2885.1990.tb00793.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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