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dc.contributor.authorMcKellar, Quintin
dc.contributor.authorPearson, T.
dc.contributor.authorGalbraith, E.A.
dc.contributor.authorBoyle, J.
dc.contributor.authorBell, G.
dc.identifier.citationMcKellar , Q , Pearson , T , Galbraith , E A , Boyle , J & Bell , G 1991 , ' Pharmacokinetics and clinical efficacy of a cinchophen and prednisolone combination in the dog ' , Journal of Small Animal Practice (JSAP) , vol. 32 , no. 2 , pp. 53-58 .
dc.identifier.otherBibtex: urn:f1c90403668f20b6d8c4c364afdaa61e
dc.description.abstractThe kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) were assessed in the dog. Cinchophen administered at a dose rate of 12-5 mg/kg intravenously had a volume of distribution (Vd area) of 0–13 litres/kg, a clearance rate (Cl) of 0–15 litres/h and a half-life (t 1/2β of 7–92 hours. Following oral administration the bioavailability was 87-21 per cent. Prednisolone administered at a dose rate of 0–15 mg/kg intravenously had a Vd area of 2–7 litres/kg, a CI of 0–116 litres/h and a t1/2β of 1–11 hours. PLT given to dogs with osteoarthritis at a dosage range of between 25 and 44 mg/kg per day cinchophen and between 0–125 and 0–220 mg/kg per day prednisolone for a maximum of 14 days significantly improved lameness (P<0–001), weight bearing (P<0–005), joint mobility (P<0–01) and stiffness (P<0–001) scores and was similar in clinical efficacy to phenylbutazoneen
dc.relation.ispartofJournal of Small Animal Practice (JSAP)
dc.titlePharmacokinetics and clinical efficacy of a cinchophen and prednisolone combination in the dogen
dc.contributor.institutionOffice of the Vice-Chancellor
dc.contributor.institutionVeterinary Science
dc.contributor.institutionGeography, Environment and Agriculture
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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