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dc.contributor.authorMcKellar, Quintin
dc.contributor.authorJackson, F.
dc.contributor.authorCoop, R. L.
dc.contributor.authorJackson, E.
dc.contributor.authorScott, E.
dc.identifier.citationMcKellar , Q , Jackson , F , Coop , R L , Jackson , E & Scott , E 1991 , ' Effect of parasitism with Nematodirus battus on the pharmacokinetics of levamisole, ivermectin and netobimin ' , Veterinary Parasitology , vol. 39 , no. 1-2 , pp. 123-36 .
dc.identifier.otherPURE: 1444578
dc.identifier.otherPURE UUID: 472b93fb-0bae-405e-9d33-cdc202901248
dc.identifier.otherPubMed: 1897114
dc.identifier.otherScopus: 0025826672
dc.description.abstractThe pharmacokinetics of levamisole, ivermectin and netobimin administered orally and by subcutaneous injection were compared in lambs exposed to a moderate challenge with Nematodirus battus and in parasite naive lambs. There were no significant differences (P greater than 0.05) in the bioavailability of any of the anthelmintics tested between parasitized and non-parasitized animals. Levamisole reduced nematode faecal egg output by more than 99% when administered by either route. Ivermectin was also highly effective (greater than 99%). Orally administered netobimin reduced egg output by more than 98% seven days after administration. However egg output was only reduced by 89% 21 days after administration, suggesting poor activity against the early parasitic stages of N. battus. Netobimin was not effective against N. battus when administered by the subcutaneous route and this was probably because very low plasma concentrations of its active albendazole metabolites were achieved.en
dc.relation.ispartofVeterinary Parasitology
dc.titleEffect of parasitism with Nematodirus battus on the pharmacokinetics of levamisole, ivermectin and netobiminen
dc.contributor.institutionOffice of the Vice-Chancellor
dc.contributor.institutionVeterinary Science
dc.contributor.institutionGeography, Environment and Agriculture
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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