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Effect of molecular weight and concentration hyaluronan on the in-vitro release characteristics of ibuprofen and diclofenac sodium across cellulose membrane

dc.contributor.authorHe, W. J.
dc.contributor.authorBrown, Marc
dc.contributor.authorMartin, Gary P.
dc.date.accessioned2014-04-15T11:30:22Z
dc.date.available2014-04-15T11:30:22Z
dc.date.issued2004-09
dc.identifier.citationHe , W J , Brown , M & Martin , G P 2004 , ' Effect of molecular weight and concentration hyaluronan on the in-vitro release characteristics of ibuprofen and diclofenac sodium across cellulose membrane ' , Journal of Pharmacy and Pharmacology , vol. 56 , no. S1 , pp. 13 . https://doi.org/10.1211/002235704777489375
dc.identifier.issn0022-3573
dc.identifier.otherPURE: 628296
dc.identifier.otherPURE UUID: 31f17e90-28d2-4f8b-b4db-e9f02121d30e
dc.identifier.otherWOS: 000203408100035
dc.identifier.otherScopus: 3242773840
dc.identifier.urihttp://hdl.handle.net/2299/13372
dc.descriptionBPC Science Abstracts
dc.description.abstractHyaluronan (HA) is a naturally occurring polyanionic glycosaminoglycan. Drugs formulated in HA and applied topically are retained in the skin with little systemic absorption (Brown et al 2000, 2001). However, the precise mechanism of action of HA that facilitates drug delivery and promotes drug localization remain unclear. In this study we investigated the in-vitro release characteristics of two NSAID drugs, ibuprofen (IBF) and diclofenac sodium (DFS), incorporated into vehicles containing four different molecular weight (MW) grades and different concentrations of HA across cellulose membraneen
dc.format.extent1
dc.language.isoeng
dc.relation.ispartofJournal of Pharmacy and Pharmacology
dc.titleEffect of molecular weight and concentration hyaluronan on the in-vitro release characteristics of ibuprofen and diclofenac sodium across cellulose membraneen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.contributor.institutionNanopharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1211/002235704777489375
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue


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