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        Risk of adult schizophrenia and its relationship to childhood IQ in the 1958 British birth cohort.

        Author
        Schulz, Joerg
        Sundin, Josefin
        Leask, S.K.
        Done, D.J.
        Attention
        2299/13421
        Abstract
        Background: An inverse relationship between risk of schizophrenia and premorbid IQ is a robust empirical finding. Cognitive impairment may be a core feature of schizophrenia in addition to the clinical symptoms that have historically defined the disorder. Aims: To evaluate whether risk of schizophrenia increases linearly or nonlinearly with the lowering of premorbid IQ after adjustment for a range of confounding factors. Methods: IQ data from the 1958 National Child Development Study, a prospective national birth cohort (n = 17 419), were linked with psychiatric admissions in England and Wales over a 20-year period. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnoses were derived from case notes. Results: A clear nonlinear inverse relationship between general intelligence at ages 7 and 11 and risk of adult psychosis was found even after adjustment for potential social, behavioral, or demographic confounding factors. No such relationship was found for affective disorders. Conclusions: The nonlinear relationship suggests an excess risk of schizophrenia in children with premorbid IQ in the learning disabilities range. Previous reports of a linear relationship are likely to be a result of less sensitive statistical methods for detecting nonlinearity
        Publication date
        2014
        Published in
        Schizophrenia Bulletin
        Published version
        https://doi.org/10.1093/schbul/sbs157
        Other links
        http://hdl.handle.net/2299/13421
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