dc.contributor.author | Stewart, C.A. | |
dc.contributor.author | Turner, Rob B. | |
dc.contributor.author | Brown, Marc | |
dc.contributor.author | Traynor, M.J. | |
dc.contributor.editor | Chilcott, Robert | |
dc.contributor.editor | Brain, Keith R. | |
dc.date.accessioned | 2014-05-28T09:00:29Z | |
dc.date.available | 2014-05-28T09:00:29Z | |
dc.date.issued | 2014-04-14 | |
dc.identifier.citation | Stewart , C A , Turner , R B , Brown , M & Traynor , M J 2014 , Classification of irritant/ non-irritant and corrosive chemicals using excised human skin in vitro . in R Chilcott & K R Brain (eds) , Advances in Dermatological Sciences . vol. 1 , Issues in Toxicology , no. 20 , Royal Society of Chemistry , pp. 308-320 . https://doi.org/10.1039/9781849734639-00308 | |
dc.identifier.isbn | 978-1849733984 | |
dc.identifier.uri | http://hdl.handle.net/2299/13555 | |
dc.description.abstract | Any chemical that is applied to the skin has the potential to induce a skin reaction. These reactions are complicated and are difficult to fully replicate in vitro and may exhibit species variations when reproduced in vivo. Skin irritation is the observed response (erythema, oedema, pain itching and heat) to chemicals that result in inflammation at the site of application. Skin irritation is defined as reversible damage of the skin following application of a chemical for up to 4 h. By contrast, skin corrosion is defined as ‘'irreversible damage to the skin, namely visible necrosis through the epidermis and into the dermis, following the application of a test substance for a period of 3 min up to 4 h”. | en |
dc.format.extent | 13 | |
dc.language.iso | eng | |
dc.publisher | Royal Society of Chemistry | |
dc.relation.ispartof | Advances in Dermatological Sciences | |
dc.relation.ispartofseries | Issues in Toxicology | |
dc.title | Classification of irritant/ non-irritant and corrosive chemicals using excised human skin in vitro | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Toxicology | |
dc.contributor.institution | Nanopharmaceutics | |
dc.contributor.institution | Bioadhesive Drug Delivery Group | |
dc.contributor.institution | Airway Group | |
dc.contributor.institution | Skin and Nail Group | |
dc.contributor.institution | Pharmaceutics | |
dc.contributor.institution | Pharmaceutical Analysis and Product Characterisation | |
dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
dc.contributor.institution | Department of Pharmacy | |
dc.contributor.institution | Health & Human Sciences Research Institute | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1039/9781849734639-00308 | |
rioxxterms.type | Other | |
herts.preservation.rarelyaccessed | true | |