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dc.contributor.authorSaid, Mazlina Mohd
dc.contributor.authorGibbons, Simon
dc.contributor.authorMoffat, Anthony C.
dc.contributor.authorZloh, Mire
dc.date.accessioned2014-06-03T12:30:27Z
dc.date.available2014-06-03T12:30:27Z
dc.date.issued2014-09-01
dc.identifier.citationSaid , M M , Gibbons , S , Moffat , A C & Zloh , M 2014 , ' Rapid detection of sildenafil analogue in Eurycoma longifolia products using a new two-tier procedure of the near infrared (NIR) spectra database ' , Food Chemistry , vol. 158 , pp. 296-301 . https://doi.org/10.1016/j.foodchem.2014.02.125
dc.identifier.issn0308-8146
dc.identifier.otherPURE: 2970121
dc.identifier.otherPURE UUID: dc5c4715-c34f-40e0-9965-a602a5ed0147
dc.identifier.otherPubMed: 24731345
dc.identifier.otherScopus: 84896486165
dc.identifier.urihttp://hdl.handle.net/2299/13596
dc.description.abstractA simple and cost-effective two-tier drug screening procedure comprises a 'dedicated' NIR spectral database of common medicines and a 'unified' database was developed to detect the sildenafil analogue in Eurycoma longifolia products. Diffuse reflectance spectra of ten commercial herbal products containing E. longifolia were obtained over the wavelength range of 1100-2500nm. The spectral search of two products purchased via the internet against a dedicated database of reputable E. longifolia products have resulted in the similarity index of more than 0.1 which indicated significantly different spectra. Further searches against the unified database showed a close match to the spectra of drug containing sildenafil citrate suggesting the presence of a sildenafil analogue. This finding was supported by clustering of these spectra in the PCA score plot within 5% significance level. This approach has alleviated the use of reference product or standard active for direct comparison and has a potential to be used for adulterated food and drugs detection.en
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofFood Chemistry
dc.titleRapid detection of sildenafil analogue in Eurycoma longifolia products using a new two-tier procedure of the near infrared (NIR) spectra databaseen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionMedicinal and Analytical Chemistry
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2014-02-23
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.foodchem.2014.02.125
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeclosedAccess


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