dc.contributor.author | Iravani, Mahmoud M. | |
dc.contributor.author | Zar, M. A. | |
dc.date.accessioned | 2014-06-09T14:00:38Z | |
dc.date.available | 2014-06-09T14:00:38Z | |
dc.date.issued | 1993-11-30 | |
dc.identifier.citation | Iravani , M M & Zar , M A 1993 , ' Differential-effects of Nifedipine on nerve-mediated and noradrenaline-evoked contractions of rat anococcygeus muscle ' , European Journal of Pharmacology , vol. 250 , no. 1 , pp. 193-195 . https://doi.org/10.1016/0014-2999(93)90643-V | |
dc.identifier.issn | 0014-2999 | |
dc.identifier.other | ORCID: /0000-0002-4905-9682/work/32997618 | |
dc.identifier.uri | http://hdl.handle.net/2299/13674 | |
dc.description.abstract | In rat anococcygeus muscle the inhibitory effect of nifedipine (0.01. 0.1, 1.0 and 10 muM) was determined on adrenergic twitches in response to electrical field stimulation (trains of 4 pulses, 0.1 ms pulse duration. 10 Hz) and on twitch-matching contractions evoked by noradrenaline. Nifedipine concentration-dependently reduced the neurogenic twitch with an IC50 of 0.083 muM. Nifedipine reduced the noradrenaline-evoked contraction to a markedly lesser degree (IC50 > 10 muM). The difference in the magnitude of inhibition of electrically evoked twitch and twitch-matching noradrenaline-evoked contraction was statistically significant at every concentration of nifedipine. It is concluded that inhibition of the twitch by nifedipine involves some other mechanism(s) in addition to its Ca2+ Channel blocking property in smooth muscle. | en |
dc.format.extent | 3 | |
dc.language.iso | eng | |
dc.relation.ispartof | European Journal of Pharmacology | |
dc.subject | ANOCOCCYGEUS MUSCLE | |
dc.subject | NIFEDIPINE | |
dc.subject | ADRENERGIC TRANSMISSION | |
dc.subject | CA2+ CHANNEL ANTAGONIST | |
dc.subject | NEUROPEPTIDE-Y | |
dc.title | Differential-effects of Nifedipine on nerve-mediated and noradrenaline-evoked contractions of rat anococcygeus muscle | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Basic and Clinical Science Unit | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1016/0014-2999(93)90643-V | |
rioxxterms.type | Other | |
herts.preservation.rarelyaccessed | true | |