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dc.contributor.authorWilliams, J. Andrew
dc.contributor.authorChenery, Richard J.
dc.contributor.authorBerkhout, Theo
dc.contributor.authorHawksworth, Gabrielle M.
dc.identifier.citationWilliams , J A , Chenery , R J , Berkhout , T & Hawksworth , G M 1997 , ' Induction of cytochrome P4503A by the antiglucocorticoid mifepristone and a novel hypocholesterolaemic drug ' , Drug Metabolism and Disposition , vol. 25 , no. 6 , pp. 757-761 .
dc.identifier.otherPURE: 7130510
dc.identifier.otherPURE UUID: fca16fac-48c5-4d14-9db5-b6575d756fbd
dc.identifier.otherScopus: 0030987376
dc.identifier.otherPubMed: 9193879
dc.description.abstractRat liver microsomal testosterone (250μM) hydroxylation and immunoreactive CYP3A protein were compared after administration of the antiglucocorticoid RU 486 (50 mg-kg-1 · day-1 for 4 days) and the hypocholesterolaemic drug SR-12813 (150 mg · kg-1 · day-1 for 4 days). Markers of CYP3A-mediated enzyme activity (testosterone 15β-1 6β-, and 2β-hydroxylation) were increased after administration of both drugs. Testosterone 6β-hydroxylation was increased 5-fold by RU 486 and 9-fold by SR-12813. Administration of dexamethasone alone at 150 mg · kg-1 · day- 1 or in combination with RU 486 induced testosterone 6β-hydroxylation 15- to 20-fold. The lack of antagonistic effect of RU 486 on dexamethasone- mediated CYP3A induction strengthens support for the hypothesis that the 'classical glucocorticoid receptor' does not play a part in this process. The induction of CYP3A enzymes by the bisphosphonate SR-12813 suggests the existence of a new class of compounds with CYP3A inducing properties.en
dc.relation.ispartofDrug Metabolism and Disposition
dc.titleInduction of cytochrome P4503A by the antiglucocorticoid mifepristone and a novel hypocholesterolaemic drugen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionMedicinal and Analytical Chemistry
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.typeJournal Article/Review

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