| dc.contributor.author | Williams, J. Andrew | |
| dc.contributor.author | Chenery, Richard J. | |
| dc.contributor.author | Berkhout, Theo | |
| dc.contributor.author | Hawksworth, Gabrielle M. | |
| dc.date.accessioned | 2014-06-11T10:00:33Z | |
| dc.date.available | 2014-06-11T10:00:33Z | |
| dc.date.issued | 1997-06-01 | |
| dc.identifier.citation | Williams , J A , Chenery , R J , Berkhout , T & Hawksworth , G M 1997 , ' Induction of cytochrome P4503A by the antiglucocorticoid mifepristone and a novel hypocholesterolaemic drug ' , Drug Metabolism and Disposition , vol. 25 , no. 6 , pp. 757-761 . | |
| dc.identifier.issn | 0090-9556 | |
| dc.identifier.other | PURE: 7130510 | |
| dc.identifier.other | PURE UUID: fca16fac-48c5-4d14-9db5-b6575d756fbd | |
| dc.identifier.other | Scopus: 0030987376 | |
| dc.identifier.other | PubMed: 9193879 | |
| dc.identifier.uri | http://hdl.handle.net/2299/13693 | |
| dc.description.abstract | Rat liver microsomal testosterone (250μM) hydroxylation and immunoreactive CYP3A protein were compared after administration of the antiglucocorticoid RU 486 (50 mg-kg-1 · day-1 for 4 days) and the hypocholesterolaemic drug SR-12813 (150 mg · kg-1 · day-1 for 4 days). Markers of CYP3A-mediated enzyme activity (testosterone 15β-1 6β-, and 2β-hydroxylation) were increased after administration of both drugs. Testosterone 6β-hydroxylation was increased 5-fold by RU 486 and 9-fold by SR-12813. Administration of dexamethasone alone at 150 mg · kg-1 · day- 1 or in combination with RU 486 induced testosterone 6β-hydroxylation 15- to 20-fold. The lack of antagonistic effect of RU 486 on dexamethasone- mediated CYP3A induction strengthens support for the hypothesis that the 'classical glucocorticoid receptor' does not play a part in this process. The induction of CYP3A enzymes by the bisphosphonate SR-12813 suggests the existence of a new class of compounds with CYP3A inducing properties. | en |
| dc.format.extent | 5 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Drug Metabolism and Disposition | |
| dc.subject | Pharmacology | |
| dc.subject | Toxicology | |
| dc.title | Induction of cytochrome P4503A by the antiglucocorticoid mifepristone and a novel hypocholesterolaemic drug | en |
| dc.contributor.institution | School of Life and Medical Sciences | |
| dc.contributor.institution | Department of Pharmacy | |
| dc.contributor.institution | Health & Human Sciences Research Institute | |
| dc.contributor.institution | Medicinal and Analytical Chemistry | |
| dc.description.status | Peer reviewed | |
| rioxxterms.type | Journal Article/Review | |
| herts.preservation.rarelyaccessed | true | |
