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Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists

dc.contributor.authorWitherington, Jason
dc.contributor.authorBordas, Vincent
dc.contributor.authorCooper, Dave G.
dc.contributor.authorForbes, Ian T.
dc.contributor.authorGribble, Andrew D.
dc.contributor.authorIfe, Robert J.
dc.contributor.authorBerkhout, Theo
dc.contributor.authorGohil, Jayneeta
dc.contributor.authorGroot, Pieter H. E.
dc.date.accessioned2014-06-11T11:30:32Z
dc.date.available2014-06-11T11:30:32Z
dc.date.issued2001-08-20
dc.identifier.citationWitherington , J , Bordas , V , Cooper , D G , Forbes , I T , Gribble , A D , Ife , R J , Berkhout , T , Gohil , J & Groot , P H E 2001 , ' Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists ' , Bioorganic and Medicinal Chemistry Letters , vol. 11 , no. 16 , pp. 2177-2180 . https://doi.org/10.1016/S0960-894X(01)00397-3
dc.identifier.issn0960-894X
dc.identifier.otherPURE: 7129500
dc.identifier.otherPURE UUID: 8f602834-7de8-45e3-9f33-57ec71f20ec0
dc.identifier.otherScopus: 0035921020
dc.identifier.otherPubMed: 11514164
dc.identifier.urihttp://hdl.handle.net/2299/13698
dc.description.abstractThe preparation and biological evaluation of a series of indolopiperidine CCR2B receptor antagonists possessing a conformationally restricted C-5 linker chain in combination with a restricted piperidine ring are described. Compared to the parent compound 1, analogue 8 shows a dramatic improvement in selectivity against a range of 5-HT and dopaminergic receptors.en
dc.format.extent4
dc.language.isoeng
dc.relation.ispartofBioorganic and Medicinal Chemistry Letters
dc.subjectBiochemistry
dc.subjectMolecular Biology
dc.subjectOrganic Chemistry
dc.subjectDrug Discovery
dc.subjectPharmaceutical Science
dc.titleConformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonistsen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionMedicinal and Analytical Chemistry
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1016/S0960-894X(01)00397-3
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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