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dc.contributor.authorChapman, Gayle A.
dc.contributor.authorMoores, Kitty E.
dc.contributor.authorGohil, Jayneeta
dc.contributor.authorBerkhout, Theo
dc.contributor.authorPatel, Lisa
dc.contributor.authorGreen, Paula
dc.contributor.authorMacPhee, Colin H.
dc.contributor.authorStewart, Brian R.
dc.identifier.citationChapman , G A , Moores , K E , Gohil , J , Berkhout , T , Patel , L , Green , P , MacPhee , C H & Stewart , B R 2000 , ' The role of fractalkine in the recruitment of monocytes to the endothelium ' , European Journal of Pharmacology , vol. 392 , no. 3 , pp. 189-195 .
dc.identifier.otherPURE: 7129657
dc.identifier.otherPURE UUID: 06f46007-47bf-4069-a5b5-c98cd2d0f253
dc.identifier.otherScopus: 0034737714
dc.identifier.otherPubMed: 10762673
dc.description.abstractRecombinant fractalkine possesses both chemoattractive and adhesive properties in vitro. Previous studies have demonstrated an upregulation of this molecule on the membranes of activated human endothelial cells and hypothesised that fractalkine plays a role in the recruitment and adherence of monocytes to the activated endothelium. Here we present data analysing both the adhesive and chemoattractive properties of this chemokine expressed by activated human umbilical vein endothelial cells. We demonstrate that both recombinant fractalkine and endogenously produced fractalkine function as adhesion molecules, tethering monocytes to the endothelium. However, our data demonstrate that although recombinant fractalkine has the potential to function as a potent monocyte chemoattractant, the endogenous fractalkine cleaved from activated human umbilical vein endothelial cells is not responsible for the observed chemotaxis in this model. Instead, we show that monocyte chemoattractant protein-1 (MCP-1), secreted from the activated human umbilical vein endothelial cells, is responsible for the chemotaxis of these monocytes. Copyright (C) 2000 Elsevier Science B.V.en
dc.relation.ispartofEuropean Journal of Pharmacology
dc.subjectEndothelial cell
dc.subjectUmbilical vein
dc.subjectCellular and Molecular Neuroscience
dc.titleThe role of fractalkine in the recruitment of monocytes to the endotheliumen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionMedicinal and Analytical Chemistry
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.typeJournal Article/Review

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