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dc.contributor.authorHall, M.R.
dc.contributor.authorPetruckevitch, A.
dc.contributor.authorPascoe, Joanna
dc.contributor.authorPersic, Mojca
dc.contributor.authorTahir, Saad
dc.contributor.authorMorgan, J.S.
dc.contributor.authorGourley, Charlie
dc.contributor.authorStuart, N.S.A.
dc.contributor.authorCrawford, S.M.
dc.contributor.authorKornbrot, D.E.
dc.contributor.authorQian, Wendi
dc.contributor.authorRustin, G.J.S.
dc.date.accessioned2014-07-01T10:31:31Z
dc.date.available2014-07-01T10:31:31Z
dc.date.issued2014-05
dc.identifier.citationHall , M R , Petruckevitch , A , Pascoe , J , Persic , M , Tahir , S , Morgan , J S , Gourley , C , Stuart , N S A , Crawford , S M , Kornbrot , D E , Qian , W & Rustin , G J S 2014 , ' Using serum CA125 to assess the activity of potential cytostatic agents in ovarian cancer ' , International Journal of Gynecological Cancer , vol. 24 , no. 4 , pp. 676-681 . https://doi.org/10.1097/IGC.0000000000000116
dc.identifier.issn1525-1438
dc.identifier.otherPURE: 7095884
dc.identifier.otherPURE UUID: 05938078-ffd9-4bc0-8aa4-cbb9201b5922
dc.identifier.otherScopus: 84900444774
dc.identifier.urihttp://hdl.handle.net/2299/13885
dc.description.abstractObjective: New strategies are required to rapidly identify novel cytostatic agents before embarking on large randomized trials. This study investigates whether a change in rate of rise (slope) of serum CA125 from before to after starting a novel agent could be used to identify cytostatic agents. Tamoxifen was used to validate this hypothesis. Methods: Asymptomatic patients with relapsed ovarian cancer who had responded to chemotherapy were enrolled and had CA125 measurements taken every 4 weeks, then more frequently when rising. Once levels reached 4 times the upper limit of normal or nadir, they started continuous tamoxifen 20 mg daily, as well as fortnightly CA125 measurements until symptomatic progression. Because of the potentially nonlinear relationship of CA125 over time, it was felt that to enable normal approximations to be utilized a natural logarithmic standard transformation [ln(CA125)] was the most suitable to improve linearity above the common logarithmic transformation to base 10. Results: From 235 recruited patients, 81 started tamoxifen and had at least 4 CA125 measurements taken before and 4 CA125 measurements taken after starting tamoxifen, respectively. The mean regression slopes from using at least 4 1n(CA125) measurements immediately before and after starting tamoxifen were 0I0149 and 0I0093 [ln(CA125)/d], respectively. This difference is statistically significant, P = 0I001. Therefore, in a future trial with a novel agent, at least as effective as tamoxifen, using this effect size, the number of evaluable patients needed, at significance level of 5% and power of 80%, is 56. Conclusions: Further validation of this methodology is required, but there is potential to use comparison of mean regression slopes of ln(CA125) as an interim analysis measure of efficacy for novel cytostatic agents in relapsed ovarian cancer.en
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofInternational Journal of Gynecological Cancer
dc.rights/dk/atira/pure/core/openaccesspermission/embargoed
dc.subjectCA125
dc.subjectNovel cytostatic agents
dc.subjectRelapsed ovary cancer
dc.subjectResponse
dc.subjectTamoxifen
dc.titleUsing serum CA125 to assess the activity of potential cytostatic agents in ovarian canceren
dc.contributor.institutionDepartment of Psychology
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPsychology
dc.contributor.institutionBehaviour Change in Health and Business
dc.contributor.institutionLearning, Memory and Cognition
dc.description.statusPeer reviewed
dc.date.embargoedUntil2015-05-01
dc.description.versiontypeFinal Accepted Version
rioxxterms.versionAM
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1097/IGC.0000000000000116
rioxxterms.licenseref.startdate2015-05-01+01:00
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.date.embargo2015-05-01+01:00
herts.rights.accesstypeopenAccess


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