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dc.contributor.authorHegedus, Andrea
dc.contributor.authorNyamweya, Samuel
dc.contributor.authorZhang, Yan
dc.contributor.authorGovind, Sheila
dc.contributor.authorAspinall, Richard
dc.contributor.authorMashanova, Alla
dc.contributor.authorJansen, Vincent A. A.
dc.contributor.authorWhittle, Hilton
dc.contributor.authorJaye, Assan
dc.contributor.authorFlanagan, Katie L
dc.contributor.authorMacallan, Derek C.
dc.date.accessioned2014-08-18T11:30:51Z
dc.date.available2014-08-18T11:30:51Z
dc.date.issued2014-09-01
dc.identifier.citationHegedus , A , Nyamweya , S , Zhang , Y , Govind , S , Aspinall , R , Mashanova , A , Jansen , V A A , Whittle , H , Jaye , A , Flanagan , K L & Macallan , D C 2014 , ' Protection Versus Pathology in Aviremic and High Viral Load HIV-2 Infection : The Pivotal Role of Immune Activation and T-cell Kinetics ' , Journal of Infectious Diseases , vol. 210 , no. 5 , pp. 752-61 . https://doi.org/10.1093/infdis/jiu165
dc.identifier.issn1537-6613
dc.identifier.otherPURE: 7372143
dc.identifier.otherPURE UUID: a25ca7dd-5a53-4d4b-880c-800d7ddead35
dc.identifier.otherPubMed: 24803534
dc.identifier.otherScopus: 84907424123
dc.identifier.urihttp://hdl.handle.net/2299/14384
dc.description© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited
dc.description.abstractBACKGROUND: Many human immunodeficiency virus (HIV)-2-infected individuals remain aviremic and behave as long-term non-progressors but some progress to AIDS. We hypothesized that immune activation and T-cell turnover would be critical determinants of non-progressor/progressor status. METHODS: We studied 37 subjects in The Gambia, West Africa: 10 HIV-negative controls, 10 HIV-2-infected subjects with low viral loads (HIV-2-LV), 7 HIV-2-infected subjects with high viral loads (HIV-2-HV), and 10 with HIV-1 infection. We measured in vivo T-cell turnover using deuterium-glucose labeling, and correlated results with T-cell phenotype (by flow cytometry) and T-cell receptor excision circle (TREC) abundance. RESULTS: Immune activation (HLA-DR/CD38 coexpression) differed between groups with a significant trend: controls <HIV-2-LV <HIV-1 <HIV-2-HV (P < .01 for all cell types). A similar trend was observed in the pattern of in vivo turnover of memory CD4(+) and CD8(+) T-cells and TREC depletion in naive CD4(+) T-cells, although naive T-cell turnover was relatively unaffected by either infection. T-cell turnover, immune activation, and progressor status were closely associated. CONCLUSIONS: HIV-2 non-progressors have low rates of T-cell turnover (both CD4(+) and CD8(+)) and minimal immune activation; high viral load HIV-2 progressors had high values, similar to or exceeding those in HIV-1 infection.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofJournal of Infectious Diseases
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.titleProtection Versus Pathology in Aviremic and High Viral Load HIV-2 Infection : The Pivotal Role of Immune Activation and T-cell Kineticsen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.contributor.institutionGeography, Environment and Agriculture
dc.contributor.institutionEcology
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1093/infdis/jiu165
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeopenAccess


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