dc.contributor.author | Hegedus, Andrea | |
dc.contributor.author | Nyamweya, Samuel | |
dc.contributor.author | Zhang, Yan | |
dc.contributor.author | Govind, Sheila | |
dc.contributor.author | Aspinall, Richard | |
dc.contributor.author | Mashanova, Alla | |
dc.contributor.author | Jansen, Vincent A. A. | |
dc.contributor.author | Whittle, Hilton | |
dc.contributor.author | Jaye, Assan | |
dc.contributor.author | Flanagan, Katie L | |
dc.contributor.author | Macallan, Derek C. | |
dc.date.accessioned | 2014-08-18T11:30:51Z | |
dc.date.available | 2014-08-18T11:30:51Z | |
dc.date.issued | 2014-09-01 | |
dc.identifier.citation | Hegedus , A , Nyamweya , S , Zhang , Y , Govind , S , Aspinall , R , Mashanova , A , Jansen , V A A , Whittle , H , Jaye , A , Flanagan , K L & Macallan , D C 2014 , ' Protection Versus Pathology in Aviremic and High Viral Load HIV-2 Infection : The Pivotal Role of Immune Activation and T-cell Kinetics ' , Journal of Infectious Diseases , vol. 210 , no. 5 , pp. 752-61 . https://doi.org/10.1093/infdis/jiu165 | |
dc.identifier.issn | 1537-6613 | |
dc.identifier.other | ORCID: /0000-0003-3273-8184/work/74071756 | |
dc.identifier.uri | http://hdl.handle.net/2299/14384 | |
dc.description | © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited | |
dc.description.abstract | BACKGROUND: Many human immunodeficiency virus (HIV)-2-infected individuals remain aviremic and behave as long-term non-progressors but some progress to AIDS. We hypothesized that immune activation and T-cell turnover would be critical determinants of non-progressor/progressor status. METHODS: We studied 37 subjects in The Gambia, West Africa: 10 HIV-negative controls, 10 HIV-2-infected subjects with low viral loads (HIV-2-LV), 7 HIV-2-infected subjects with high viral loads (HIV-2-HV), and 10 with HIV-1 infection. We measured in vivo T-cell turnover using deuterium-glucose labeling, and correlated results with T-cell phenotype (by flow cytometry) and T-cell receptor excision circle (TREC) abundance. RESULTS: Immune activation (HLA-DR/CD38 coexpression) differed between groups with a significant trend: controls <HIV-2-LV <HIV-1 <HIV-2-HV (P < .01 for all cell types). A similar trend was observed in the pattern of in vivo turnover of memory CD4(+) and CD8(+) T-cells and TREC depletion in naive CD4(+) T-cells, although naive T-cell turnover was relatively unaffected by either infection. T-cell turnover, immune activation, and progressor status were closely associated. CONCLUSIONS: HIV-2 non-progressors have low rates of T-cell turnover (both CD4(+) and CD8(+)) and minimal immune activation; high viral load HIV-2 progressors had high values, similar to or exceeding those in HIV-1 infection. | en |
dc.format.extent | 10 | |
dc.format.extent | 432454 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Infectious Diseases | |
dc.title | Protection Versus Pathology in Aviremic and High Viral Load HIV-2 Infection : The Pivotal Role of Immune Activation and T-cell Kinetics | en |
dc.contributor.institution | Department of Human and Environmental Sciences | |
dc.contributor.institution | Health & Human Sciences Research Institute | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Agriculture, Food and Veterinary Sciences | |
dc.contributor.institution | Geography, Environment and Agriculture | |
dc.contributor.institution | Ecology | |
dc.contributor.institution | Crop Protection and Climate Change | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1093/infdis/jiu165 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |