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        Evidence for the existence of powder sub-populations in micronized materials : Aerodynamic size-fractions of aerosolized powders possess distinct physicochemical properties

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        Pharm_Res_Jaffari_10.1007_s11095_014_1414_3.pdf (PDF, 926Kb)
        Author
        Jaffari, Sara
        Forbes, Ben
        Collins, Elizabeth
        Khoo, Jiyi
        Martin, Gary P.
        Murnane, Darragh
        Attention
        2299/14773
        Abstract
        Purpose: To investigate the agglomeration behaviour of the fine (< 5.0 µm) and coarse (> 12.8 µm) particle fractions of salmeterol xinafoate (SX) and fluticasone propionate (FP) by isolating aerodynamic size fractions and characterising their physicochemical and re-dispersal properties. Methods: Aerodynamic fractionation was conducted using the Next Generation Impactor (NGI). Re-crystallized control particles, unfractionated and fractionated materials were characterized for particle size, morphology, crystallinity and surface energy. Re-dispersal of the particles was assessed using dry dispersion laser diffraction and NGI analysis. Results: Aerosolized SX and FP particles deposited in the NGI as agglomerates of consistent particle/agglomerate morphology. SX particles depositing on Stages 3 and 5 had higher total surface energy than unfractionated SX, with Stage 5 particles showing the greatest surface energy heterogeneity. FP fractions had comparable surface energy distributions and bulk crystallinity but differences in surface chemistry. SX fractions demonstrated higher bulk disorder than unfractionated and re-crystallized particles. Upon aerosolization, the fractions differed in their intrinsic emission and dispersion into a fine particle fraction (< 5.0 µm). Conclusions: Micronized powders consisted of sub-populations of particles displaying distinct physicochemical and powder dispersal properties compared to the unfractionated bulk material. This may have implications for the efficiency of inhaled drug delivery
        Publication date
        2014-12-31
        Published in
        Pharmaceutical Research
        Published version
        https://doi.org/10.1007/s11095-014-1414-3
        Other links
        http://hdl.handle.net/2299/14773
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