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dc.contributor.authorBrown, Marc
dc.contributor.authorJones, Stuart A.
dc.contributor.authorHe, Weijiang
dc.contributor.authorMartin, Gary P.
dc.contributor.editorMarchessault, R.H.
dc.contributor.editorRavenelle, F.
dc.contributor.editorZhu, X.X.
dc.identifier.citationBrown , M , Jones , S A , He , W & Martin , G P 2006 , Hyaluronan: Investigations into the mode of action of hyaluronan in topical drug delivery . in R H Marchessault , F Ravenelle & X X Zhu (eds) , Polysaccharides for Drug Delivery and Pharmaceutical Applications . American Chemical Society , Washington , pp. 141-153 , Symposium on Polysaccharides for Drug Delivery and Pharmaceutical Applications held at the 228th ACS National Meeting , Philadelphia , 22/08/04 .
dc.identifier.otherPURE: 627928
dc.identifier.otherPURE UUID: 73acbc64-879c-40f2-a7ab-9ff0e0957227
dc.identifier.otherWOS: 000239744300007
dc.identifier.otherScopus: 36949034491
dc.description.abstractHyaluronan (HA) is a polyanionic, polysaccharide ubiquitous in mammals where it has a protective, structure stabilising and shock-absorbing role. The unique viscoelastic nature of HA along with its biocompatibility and non-immunogenicity has led to its use in a number of clinical applications. The ability of HA to localise therapeutic agents in the superficial layers of the skin has led to the commericalisation of Solaraze((R)), a 3% diclofenac in 2.5% HA gel, for the topical treatment of actinic keratoses (AKs), the third most common skin complaint in the US. However, the means by which HA enhances topical drug delivery remains unclear. The data described in this study demonstrate that HA offers promotes the delivery and localisation of drugs in the skin. In addition, it would appear that the molecular weight and concentration of HA may be critical for such drug delivery properties. (c) 2006 American Chemical Societyen
dc.publisherAmerican Chemical Society
dc.relation.ispartofPolysaccharides for Drug Delivery and Pharmaceutical Applications
dc.subjectACID GEL
dc.titleHyaluronan: Investigations into the mode of action of hyaluronan in topical drug deliveryen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group

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