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dc.contributor.authorRogers, Samantha
dc.contributor.authorHughes, Beverly A.
dc.contributor.authorJones, Christopher A.
dc.contributor.authorFreedman, Lauren
dc.contributor.authorSmart, Katherine
dc.contributor.authorTaylor, Norman
dc.contributor.authorStewart, Paul M.
dc.contributor.authorShackleton, Cedric H.L.
dc.contributor.authorKrone, Nils P.
dc.contributor.authorBlissett, Jacqueline
dc.contributor.authorTomlinson, Jeremy W.
dc.date.accessioned2014-12-10T11:32:24Z
dc.date.available2014-12-10T11:32:24Z
dc.date.issued2014-05-01
dc.identifier.citationRogers , S , Hughes , B A , Jones , C A , Freedman , L , Smart , K , Taylor , N , Stewart , P M , Shackleton , C H L , Krone , N P , Blissett , J & Tomlinson , J W 2014 , ' Diminished 11 Beta-Hydroxysteroid Dehydrogenase Type 2 Activity Is Associated With Decreased Weight and Weight Gain Across the First Year of Life. ' , Journal of Clinical Endocrinology and Metabolism , vol. 99 , no. 5 , pp. E821-E831 . https://doi.org/10.1210/jc.2013-3254
dc.identifier.issn0021-972X
dc.identifier.otherPURE: 7828552
dc.identifier.otherPURE UUID: 92a636bd-2680-4d38-9035-068efcc2672d
dc.identifier.otherScopus: 84899903193
dc.identifier.urihttp://hdl.handle.net/2299/14902
dc.descriptionThis is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Clinical Endocrinology & Metabolism following peer review. The version of record [Samantha L. Rogers, et al, 'Diminished 11β-Hydroxysteroid Dehydrogenase Type 2 Activity Is Associated With Decreased Weight and Weight Gain Across the First Year of Life', The Journal of Clinical Endocrinology & Metabolism, Vol. 99 (5): E821-E832, May 2014] is available online at:https://doi.org/10.1210/jc.2013-3254
dc.description.abstractObjective: We have hypothesized that changes in GC metabolism leading to increased availability may impair growth. Design: This was a prospective, longitudinal study with clinical measurements and 24-hour urinary steroid metabolite analysis at 1, 4, 12, 26, and 52 weeks after delivery in mothers and their babies. Setting: The study was conducted with observations and samples collected in the volunteers’ own homes. Participants: Healthy mothers and newborn babies/infants participated in the study. Interventions: There were no interventions. Main outcome measures: Urinary steroid metabolite excretion quantified by gas chromatography/ mass spectroscopy across the first year of life in relation to change in weight was measured. Results: The total production of the GC metabolites quantified increased across the first year of life. Markers of 11ﰀ-hydroxysteroid dehydrogenase type 1 activity increased from the age of 3 months as did those of 5ﰂ-reductase activity. After correcting for confounding variables, low markers of 11ﰀ-hydroxysteroid dehydrogenase type 2 activity was associated with reduced absolute weight and decreased weight gain over the first year of life. In the mothers, 5ﰂ-reductase activity was low at birth and progressively increased to normal over the first 6 months postpartum. Conclusions: Increased GC exposure as a consequence of reduced 11ﰀ-hydroxysteroid dehydro- genase type 2 activity is likely to be a critical determinant of growth in early life. This not only highlights the central role of GCs and their metabolism, but also emphasizes the need for detailed longitudinal analyses.en
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolism
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.subjectcortisol
dc.subjectWeight
dc.subjectMetabolism
dc.titleDiminished 11 Beta-Hydroxysteroid Dehydrogenase Type 2 Activity Is Associated With Decreased Weight and Weight Gain Across the First Year of Life.en
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Psychology
dc.contributor.institutionPsychology
dc.contributor.institutionPublic Health and Communities
dc.contributor.institutionWeight and Obesity Research Group
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2014-01-06
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1210/jc.2013-3254
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeopenAccess


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