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dc.contributor.authorBesharati, Sahba
dc.contributor.authorForkel, Stephanie J
dc.contributor.authorKopelman, Michael
dc.contributor.authorSolms, Mark
dc.contributor.authorJenkinson, Paul M.
dc.contributor.authorFotopoulou, Aikaterini
dc.date.accessioned2014-12-15T09:17:27Z
dc.date.available2014-12-15T09:17:27Z
dc.date.issued2015-05-01
dc.identifier.citationBesharati , S , Forkel , S J , Kopelman , M , Solms , M , Jenkinson , P M & Fotopoulou , A 2015 , ' The affective modulation of motor awareness in anosognosia for hemiplegia : Behavioural and lesion evidence ' , Cortex , vol. 61 , pp. 127-40 . https://doi.org/10.1016/j.cortex.2014.08.016
dc.identifier.issn0010-9452
dc.identifier.otherPURE: 7837595
dc.identifier.otherPURE UUID: 2ae072b9-99a2-4ba9-bf3a-ee4d8a328193
dc.identifier.otherPubMed: 25481471
dc.identifier.otherScopus: 84914175524
dc.identifier.urihttp://hdl.handle.net/2299/14933
dc.description© 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.description.abstractThe possible role of emotion in anosognosia for hemiplegia (i.e., denial of motor deficits contralateral to a brain lesion), has long been debated between psychodynamic and neurocognitive theories. However, there are only a handful of case studies focussing on this topic, and the precise role of emotion in anosognosia for hemiplegia requires empirical investigation. In the present study, we aimed to investigate how negative and positive emotions influence motor awareness in anosognosia. Positive and negative emotions were induced under carefully-controlled experimental conditions in right-hemisphere stroke patients with anosognosia for hemiplegia (n = 11) and controls with clinically normal awareness (n = 10). Only the negative, emotion induction condition resulted in a significant improvement of motor awareness in anosognosic patients compared to controls; the positive emotion induction did not. Using lesion overlay and voxel-based lesion-symptom mapping approaches, we also investigated the brain lesions associated with the diagnosis of anosognosia, as well as with performance on the experimental task. Anatomical areas that are commonly damaged in AHP included the right-hemisphere motor and sensory cortices, the inferior frontal cortex, and the insula. Additionally, the insula, putamen and anterior periventricular white matter were associated with less awareness change following the negative emotion induction. This study suggests that motor unawareness and the observed lack of negative emotions about one's disabilities cannot be adequately explained by either purely motivational or neurocognitive accounts. Instead, we propose an integrative account in which insular and striatal lesions result in weak interoceptive and motivational signals. These deficits lead to faulty inferences about the self, involving a difficulty to personalise new sensorimotor information, and an abnormal adherence to premorbid beliefs about the body.en
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofCortex
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.subjectanosognosia
dc.subjectmotor awareness
dc.subjectemotion
dc.subjectinsula
dc.subjectbasal ganglia
dc.subjectVLSM
dc.titleThe affective modulation of motor awareness in anosognosia for hemiplegia : Behavioural and lesion evidenceen
dc.contributor.institutionDepartment of Psychology
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionPsychology
dc.contributor.institutionCognitive Neuropsychology
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2014-08-03
rioxxterms.versionAM
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.cortex.2014.08.016
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeopenAccess


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