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        Role of prostacyclin in pulmonary hypertension

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        907160.pdf (PDF, 381Kb)
        Author
        Mitchell, Jane A.
        Ahmetaj-Shala, Blerina
        Kirkby, Nick
        Wright, William R.
        MacKenzie, Louise Susan
        Reed, Dan
        Mohamed, Nura
        Attention
        2299/15089
        Abstract
        Prostacyclin is a powerful cardioprotective hormone released by the endothelium of all blood vessels. Prostacyclin exists in equilibrium with other vasoactive hormones and a disturbance in the balance of these factors leads to cardiovascular disease including pulmonary arterial hypertension. Since it’s discovery in the 1980s concerted efforts have been made to make the best therapeutic utility of prostacyclin, particularly in the treatment of pulmonary arterial hypertension. This has centred on working out the detailed pharmacology of prostacyclin and then synthesising new molecules based on its structure that are more stable or more easily tolerated. In addition, newer molecules have been developed that are not analogues of prostacyclin but that target the receptors that prostacyclin activates. Prostacyclin and related drugs have without doubt revolutionised the treatment and management of pulmonary arterial hypertension but are seriously limited by side effects within the systemic circulation. With the dawn of nanomedicine and targeted drug or stem cell delivery systems it will, in the very near future, be possible to make new formulations of prostacyclin that can evade the systemic circulation allowing for safe delivery to the pulmonary vessels. In this way, the full therapeutic potential of prostacyclin can be realised opening the possibility that pulmonary arterial hypertension will become, if not curable, a chronic manageable disease that is no longer fatal. This review discusses these and other issues relating to prostacyclin and its use in pulmonary arterial hypertension
        Publication date
        2014-12-31
        Published in
        Global Cardiology Science and Practice
        Published version
        https://doi.org/10.5339/gcsp.2014.53
        Other links
        http://hdl.handle.net/2299/15089
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