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dc.contributor.authorPatel, Viralkumar
dc.contributor.authorSarai, J.
dc.identifier.citationPatel , V & Sarai , J 2014 , ' Synergistic effect of hydrotrope and surfactant on solubility and dissolution of atorvastatin calcium : Screening factorial design followed by ratio optimization ' , Indian Journal of Pharmaceutical Sciences , vol. 76 , no. 6 , pp. 483-494 . <;year=2014;volume=76;issue=6;spage=483;epage=494;aulast=Patel >
dc.identifier.otherPURE: 7933261
dc.identifier.otherPURE UUID: 7c111fd3-b7b6-47e0-b2a5-a5351a62c66d
dc.identifier.otherScopus: 84920191439
dc.descriptionDate of Acceptance: 10/09/2014
dc.description.abstractThe present study was aimed at investigating the effect of hydrotrope and surfactant on poor solubility of atorvastatin calcium. Excipients screening followed by factorial design was performed to study effect of excipients and manufacturing methods on solubility of drug. Three independent factors (carrier, surfactant and manufacturing method) were evaluated at two levels using solubility as a dependant variable. Solid-state characterisation was performed using Fourier transform infrared spectroscopy and differential scanning calorimetry. Optimised complex were incorporated into orally disintegrating micro tablets and in vitro dissolution test was performed. Nicotinamide, Plasdone and sodium dodecyl sulphate were emerged as promising excipients from excipient screening. General regression analysis revealed only the type of carrier has significantly enhanced (P<0.05) the solubility of drug while other factors were found to be nonsignificant. Ratio optimisation trial revealed that drug to nicotinamide ratio is more critical in enhancing the solubility of drug (40 fold increases in solubility compared to pure drug) in comparison to drug-surfactant ratio; however the presence of surfactant deemed essential. Significantly higher rate and extent of dissolution was observed from solid dispersion complex and tablets compared to dissolution of pure drug (P<0.05). Study revealed hydrotrope and surfactant have synergistic effect on solubility and dissolution of atorvastatin calcium and this can be explored further.en
dc.relation.ispartofIndian Journal of Pharmaceutical Sciences
dc.subjectAtorvastatin calcium
dc.subjectorally disintegrating microtablets
dc.subjectsolid dispersions
dc.subjectFactorial design
dc.titleSynergistic effect of hydrotrope and surfactant on solubility and dissolution of atorvastatin calcium : Screening factorial design followed by ratio optimizationen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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