Oral Delivery of Hydrophilic Drugs to the Brain

Author

Centre for Research into Topical Drug Delivery and Toxicology

Nanopharmaceutics

Pharmaceutics

Department of Pharmacy

School of Life and Medical Sciences

Health & Human Sciences Research Institute

Lalatsa, Aikaterini

Abstract

A composition comprising a lipophilic derivative of a hydrophilic drug and an amphiphile compound for use in therapy wherein the composition is orally administered to the human or animal body. The invention includes derivatives such as palmitoylated Leucine[5]-Enkephalin and is useful in the treatment of schizophrenia, obsesity, pain and sleep disorders, psychiatric diseases, neurodegenerative conditions, brain cancers and infective diseases.