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dc.contributor.authorEsposito, M.
dc.contributor.authorAnaxagoras, T.
dc.contributor.authorLarner, Joanne
dc.contributor.authorAllinson, N.M.
dc.contributor.authorWells, K.
dc.identifier.citationEsposito , M , Anaxagoras , T , Larner , J , Allinson , N M & Wells , K 2013 , ' 14C Autoradiography with a novel wafer scale CMOS Active Pixel Sensor ' , Journal of Instrumentation , vol. 8 , C01001 .
dc.identifier.otherPURE: 8145355
dc.identifier.otherPURE UUID: ee494ea4-b15b-48be-b0ea-4683eb42d544
dc.identifier.otherScopus: 84875510106
dc.description.abstract14C autoradiography is a well established technique for structural and metabolic analysis of cells and tissues. The most common detection medium for this application is film emulsion, which offers unbeatable spatial resolution due to its fine granularity but at the same time has some limiting drawbacks such as poor linearity and rapid saturation. In recent years several digital detectors have been developed, following the technological transition from analog to digital-based detection systems in the medical and biological field. Even so such digital systems have been greatly limited by the size of their active area (a few square centimeters), which have made them unsuitable for routine use in many biological applications where sample areas are typically ∼ 10– 100 cm2 . The Multidimensional Integrated Intelligent Imaging (MI3-Plus) consortium has recently developed a new large area CMOS Active Pixel Sensor (12.8cm × 13.1 cm). This detector, based on the use of two different pixel resolutions, is capable of providing simultaneously low noise and high dynamic range on a wafer scale. In this paper we will demonstrate the suitability of this detector for routine beta autoradiography in a comparative approach with widely used film emulsion.en
dc.relation.ispartofJournal of Instrumentation
dc.title14C Autoradiography with a novel wafer scale CMOS Active Pixel Sensoren
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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