Show simple item record

dc.contributor.authorLi, Jinzhao
dc.contributor.authorRen, Ling
dc.contributor.authorZhang, Shuyuan
dc.contributor.authorRen, Guogang
dc.contributor.authorYang, Ke
dc.identifier.citationLi , J , Ren , L , Zhang , S , Ren , G & Yang , K 2015 , ' Cu-bearing steel reduce inflammation after stent implantation ' , Journal of Material Science: Materials in Medicine , vol. 26 , no. 2 , 114 .
dc.identifier.otherPURE: 8122447
dc.identifier.otherPURE UUID: 58554a68-e2b1-4093-8aef-e9a5f8b89d8f
dc.identifier.otherPubMed: 25665852
dc.identifier.otherScopus: 84922765466
dc.identifier.otherPubMed: 25665852
dc.identifier.otherORCID: /0000-0001-8865-1526/work/32373250
dc.description.abstractCopper (Cu)-bearing stainless steel with release of Cu(2+) ions is a novel material for coronary stents that could reduce the in-stent restenosis after the stent implantation. The inflammation has been recently recognized as an important factor to smooth muscle cells proliferation, thrombosis, and hence the restenosis post-angioplasty. The objective of this study is to further investigate the effect and relevant mechanism of Cu-bearing stainless steel (316L-Cu SS) on the inflammation reaction after stent implantation. The results demonstrated that, compared with commercial coronary stent material (316L SS), 316L-Cu SS could inhibit the inflammation caused by endothelial dysfunction through blockading the inflammatory factors (TNF-α, IL-1β, 6, 8), which would then reduce the recruitment and infiltration of leukocytes, rather than have direct effect on leukocytes. This finding further explained the reduction effect of 316L-Cu SS on in-stent restenosis from a novel view.en
dc.relation.ispartofJournal of Material Science: Materials in Medicine
dc.subjectChemical Engineering(all)
dc.titleCu-bearing steel reduce inflammation after stent implantationen
dc.contributor.institutionSchool of Engineering and Technology
dc.contributor.institutionScience & Technology Research Institute
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionMaterials and Structures
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record