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dc.contributor.authorYip, C.
dc.contributor.authorDavnall, F.
dc.contributor.authorKozarski, R.
dc.contributor.authorLandau, D. B.
dc.contributor.authorCook, G. J R
dc.contributor.authorRoss, P.
dc.contributor.authorMason, R.
dc.contributor.authorGoh, V.
dc.date.accessioned2015-03-03T11:48:27Z
dc.date.available2015-03-03T11:48:27Z
dc.date.issued2015-02
dc.identifier.citationYip , C , Davnall , F , Kozarski , R , Landau , D B , Cook , G J R , Ross , P , Mason , R & Goh , V 2015 , ' Assessment of changes in tumor heterogeneity following neoadjuvant chemotherapy in primary esophageal cancer ' , Diseases of the Esophagus , vol. 28 , no. 2 , pp. 172-179 . https://doi.org/10.1111/dote.12170
dc.identifier.issn1120-8694
dc.identifier.otherPURE: 7719132
dc.identifier.otherPURE UUID: 204263d3-ecb2-459c-9d24-d51d246f4ae6
dc.identifier.otherScopus: 84923436431
dc.identifier.urihttp://hdl.handle.net/2299/15520
dc.description.abstractTo assess the changes in computed tomography (CT) tumor heterogeneity following neoadjuvant chemotherapy in esophageal cancer. Thirty-one consecutive patients who received neoadjuvant chemotherapy for esophageal cancer were identified. Analysis of primary tumor heterogeneity (texture) was performed on staging and post-chemotherapy CT scans. Image texture parameters (mean grey-level intensity, entropy, uniformity, kurtosis, skewness, standard deviation of histogram) were derived for different levels of image filtration (0-2.5). Proportional changes in each parameter following treatment were obtained. Comparison between pathological tumor response and texture parameters was analyzed using Mann-Whitney U-test. The relationship between CT texture and overall survival) was estimated using the Kaplan-Meier method. Tumor texture became more homogeneous after treatment with a significant decrease in entropy and increase in uniformity (filter 1.0 and 2.5). Pretreatment (filter 1.5, P = 0.006) and posttreatment standard deviation of histogram (filter 1.0, P = 0.009) showed a borderline association with pathological tumor response. A proportional change in skewness <0.39 (filter 1.0) was associated with improved survival (median overall survival 36.1 vs. 11.1 months; P < 0.001). CT tumor heterogeneity decreased following neoadjuvant chemotherapy and has the potential to provide additional information in primary esophageal cancer.en
dc.language.isoeng
dc.relation.ispartofDiseases of the Esophagus
dc.subjectCT
dc.subjectEsophageal cancer
dc.subjectNeoadjuvant chemotherapy
dc.subjectPrognosis
dc.subjectTexture analysis
dc.subjectGastroenterology
dc.titleAssessment of changes in tumor heterogeneity following neoadjuvant chemotherapy in primary esophageal canceren
dc.contributor.institutionDepartment of Psychology
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionCentre for Lifespan and Chronic Illness Research
dc.contributor.institutionHealth Services and Medicine
dc.contributor.institutionDepartment of Allied Health Professions and Midwifery
dc.contributor.institutionSchool of Health and Social Work
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.relation.schoolSchool of Health and Social Work
dcterms.dateAccepted2015-02
rioxxterms.versionofrecordhttps://doi.org/10.1111/dote.12170
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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