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dc.contributor.authorNan, Li
dc.contributor.authorYang, Ke
dc.contributor.authorRen, Guogang
dc.date.accessioned2015-04-14T07:18:57Z
dc.date.available2015-04-14T07:18:57Z
dc.date.issued2015-06-01
dc.identifier.citationNan , L , Yang , K & Ren , G 2015 , ' Anti-biofilm formation of a novel stainless steel against Staphylococcus aureus ' , Materials Science and Engineering C: Materials for Biological Applications , vol. 51 , pp. 356-361 . https://doi.org/10.1016/j.msec.2015.03.012
dc.identifier.issn0928-4931
dc.identifier.otherPURE: 8391744
dc.identifier.otherPURE UUID: f21786cc-74b0-4980-b1c1-aeebbc49485b
dc.identifier.otherScopus: 84925620068
dc.identifier.otherORCID: /0000-0001-8865-1526/work/32373245
dc.identifier.urihttp://hdl.handle.net/2299/15767
dc.description© 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.description.abstractAbstract Staphylococcus aureus (S. aureus) is a bacterium frequently found proliferating on metal surfaces such as stainless steels used in healthcare and food processing facilities. Past research has shown that a novel Cu-bearing 304 type stainless steel (304CuSS) exhibits excellent antibacterial ability (i.e. against S. aureus) in a short time period (24 h.). This work was dedicated to investigate the 304CuSS's inhibition ability towards the S. aureus biofilm formation for an extended period of 7 days after incubation. It was found that the antibacterial rate of the 304CuSS against sessile bacterial cells reached over 99.9% in comparison with the 304SS. The thickness and sizes of the biofilms on the 304SS surfaces increased markedly with period of contact, and thus expected higher risk of bio-contamination, indicated by the changes of surface free energy between biofilm and the steel surfaces. The results demonstrated that the 304CuSS exhibited strong inhibition on the growth and adherence of the biofilms. The surface free energy of the 304CuSS after contact with sessile bacterial cells was much lower than that of the 304SS towards the same culture times. The continuously dissolved Cu2+ ions well demonstrated the dissolution ability of Cu-rich precipitates after exposure to S. aureus solution, from 3.1 ppm (2 days) to 4.5 ppm (7 days). For this to occur, a hypothesis mechanism might be established for 304CuSS in which the Cu2+ ions were released from Cu-rich phases that bond with extracellular polymeric substances (EPS) of the microorganisms. And these inhibited the activities of cell protein/enzymes and effectively prevented planktonic bacterial cells attaching to the 304CuSS metal surface.en
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofMaterials Science and Engineering C: Materials for Biological Applications
dc.rightsOpen
dc.subjectAntibacterial
dc.subjectBiofilm
dc.subjectCu-bearing stainless steel
dc.subjectS. aureus
dc.subjectMaterials Science(all)
dc.subjectCondensed Matter Physics
dc.subjectMechanical Engineering
dc.subjectMechanics of Materials
dc.titleAnti-biofilm formation of a novel stainless steel against Staphylococcus aureusen
dc.contributor.institutionSchool of Engineering and Technology
dc.contributor.institutionScience & Technology Research Institute
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionMaterials and Structures
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Engineering and Technology
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2015-06-01
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.msec.2015.03.012
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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