Cerebellar output controls generalized spike-and-wave discharge occurence
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Author
Kros, Lieke
Eelkman Rooda, Oscar
Spanke, Jochen
Alva, Parimala
van Dongen, Marijn
Karapatis, Athanasios
Tolner, Else
Strydis, Christos
Davey, N.
Winkelman, Beerend
Negrello, Mario
Serdijn, Wouter
Steuber, Volker
van den Maagdenberg, Arn
De Zeeuw, Chris I.
Hoebeek, Freek E.
Attention
2299/15989
Abstract
Disrupting thalamocortical activity patterns has proven to be a promising approach to stop generalized spike-and-wave discharges (GSWDs) characteristic of absence seizures. Here, we investigated to what extent modulation of neuronal firing in cerebellar nuclei (CN), which are anatomically in an advantageous position to disrupt cortical oscillations through their innervation of a wide variety of thalamic nuclei, is effective in controlling absence seizures