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dc.contributor.authorDavies, Keith G.
dc.contributor.authorZimmerman, Brian
dc.contributor.authorDudley, Ed
dc.contributor.authorNewton, Russell
dc.contributor.authorHart, John E.
dc.date.accessioned2015-06-03T14:06:08Z
dc.date.available2015-06-03T14:06:08Z
dc.date.issued2015-03-01
dc.identifier.citationDavies , K G , Zimmerman , B , Dudley , E , Newton , R & Hart , J E 2015 , ' Reproduction potentiated in nematodes (Caenorhabditis elegans) and guppy fish (Poecilia reticulata) by adding a synthetic peptide to their aqueous environment ' , Journal of Experimental Biology , vol. 218 , doi:10.1242/jeb.113837 , pp. 778-785 . https://doi.org/10.1242/jeb.113837
dc.identifier.issn0022-0949
dc.identifier.otherPURE: 7697886
dc.identifier.otherPURE UUID: d666d76b-20da-4173-9036-839cd5139cbe
dc.identifier.otherScopus: 84964253245
dc.identifier.urihttp://hdl.handle.net/2299/15997
dc.descriptionThis document is the Accepted Manuscript version of an article accepted for publication in Journal of Experimental Biology following peer review. The final, definitive version of this paper is available online at doi: https://doi.org/10.1242/jeb.113837.
dc.description.abstractAmbient exposure to a short synthetic peptide has enhanced fecundity (number of offspring) in invertebrates and vertebrates, ostensibly by disinhibiting reproduction. In separate experiments nematodes (Caenorhabditis elegans) and guppy fish (Poecilia reticulate) were exposed via their aqueous environment to a dissolved synthetic hexamer peptide, IEPVFT (EPL036), at a concentration of 1 μM. In the case of the worms peptide was added to their aqueous buffer daily throughout the experiment (14 days); in the guppies peptide administration was on the first 15 alternate days in a 50-week experiment. Fecundity rose by 79% among the worms. The number of descendants of the treated guppies was more than four times that of controls by Week 26 (103 vs 25), with double the estimated biomass. It was deduced that treated females bred earlier, at a smaller size, and had larger brood sizes. The total number of fish in the control tank had caught up by termination, but biomass continued to lag the test tank. There were no overt signs of toxicity among either the worms or the fish. Bioinformatics has been unilluminating in explaining these results in terms of mimicry of an endogenous regulator. A mass spectrometric campaign to identify a receptor proved inconclusive. Molecular modelling in silico indicated unexpectedly that the 6mer EPL036 might be acting as an antagonist, to pro-fecundity effect; that is, as an inhibitor of an inhibitor. This suggests that there awaits discovery an evolutionarily conserved reproductive inhibitor and its (anti-fecundity) receptor.en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofJournal of Experimental Biology
dc.rightsEmbargoed
dc.subjectBreeding
dc.subjectFertility
dc.subjectFecundity
dc.subjectAphrodisiac
dc.subjectInfertility
dc.subjectPhysiology
dc.subjectEndocrinology
dc.titleReproduction potentiated in nematodes (Caenorhabditis elegans) and guppy fish (Poecilia reticulata) by adding a synthetic peptide to their aqueous environmenten
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.contributor.institutionGeography, Environment and Agriculture
dc.contributor.institutionCrop and Environmental Protection
dc.description.statusPeer reviewed
dc.date.embargoedUntil2016-03-23
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2015-03-01
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1242/jeb.113837
rioxxterms.licenseref.startdate2016-03-23
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.date.embargo2016-03-23
herts.rights.accesstypeEmbargoed


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