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dc.contributor.authorStankiewicz, Elzbieta
dc.contributor.authorProwse, David M.
dc.contributor.authorKtori, Elena
dc.contributor.authorCuzick, Jack
dc.contributor.authorAmbroisine, Laurence
dc.contributor.authorZhang, Xiaoxi
dc.contributor.authorKudahetti, Sakunthala
dc.contributor.authorWatkin, Nicholas
dc.contributor.authorCorbishley, Catherine
dc.contributor.authorBerney, Daniel M.
dc.date.accessioned2015-06-30T07:21:18Z
dc.date.available2015-06-30T07:21:18Z
dc.date.issued2011-02-01
dc.identifier.citationStankiewicz , E , Prowse , D M , Ktori , E , Cuzick , J , Ambroisine , L , Zhang , X , Kudahetti , S , Watkin , N , Corbishley , C & Berney , D M 2011 , ' The retinoblastoma protein/p16 INK4A pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma ' , Histopathology , vol. 58 , no. 3 , pp. 433-439 . https://doi.org/10.1111/j.1365-2559.2011.03762.x
dc.identifier.issn0309-0167
dc.identifier.urihttp://hdl.handle.net/2299/16101
dc.description.abstractAims: The pathogenesis of penile squamous cell carcinoma (PSCC) is not well understood. Human papillomavirus (HPV) may be involved in carcinogenesis, but few studies have compared cell-cycle protein expression in HPV positive and negative cancers. The aim was to determine the extent of HPV infection in different histological subtypes of PSCC and its impact on the expression of key cell-cycle proteins: p53, p21, p16INK4A and retinoblastoma (RB) protein. Methods and results: One hundred and forty-eight PSCC samples were examined immunohistochemically for RB, p16INK4A, p53 and p21 protein expression. One hundred and two cases were typed for HPV by PCR. HPV DNA was detected in 56% of tumours, with HPV16 present in 81%. Basaloid tumours were related strongly to HPV infection (10 of 13), while verrucous were not (three of 13). Fifty-nine per cent (38 of 64) of usual type SCCs had HPV infection. RB protein correlated negatively (P<0.0001) and p16INK4A (P<0.0001) and p21 (P=0.0002) correlated positively with HPV infection. p53 did not correlate with HPV infection. Conclusions: HPV infection is present in more than half of penile cancers and it is responsible for RB pathway disruption. However, no link between HPV and p53 immunodetection was found. Only basaloid and half of usual-type PSSCs correlate with HPV infection, confirming possible separate aetiologies for those tumours.en
dc.format.extent7
dc.format.extent185259
dc.language.isoeng
dc.relation.ispartofHistopathology
dc.subjectHuman papillomavirus
dc.subjectP16
dc.subjectP21
dc.subjectP53
dc.subjectPenile squamous cell carcinoma
dc.subjectRetinoblastoma
dc.subjectHistology
dc.subjectPathology and Forensic Medicine
dc.titleThe retinoblastoma protein/p16INK4A pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinomaen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionBiosciences Research Group
dc.description.statusPeer reviewed
rioxxterms.versionofrecord10.1111/j.1365-2559.2011.03762.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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