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dc.contributor.authorStankiewicz, Elzbieta
dc.contributor.authorKudahetti, Sakunthala C.
dc.contributor.authorProwse, David M.
dc.contributor.authorKtori, Elena
dc.contributor.authorCuzick, Jack
dc.contributor.authorAmbroisine, Laurence
dc.contributor.authorZhang, Xiaoxi
dc.contributor.authorWatkin, Nicholas
dc.contributor.authorCorbishley, Catherine
dc.contributor.authorBerney, Daniel M.
dc.date.accessioned2015-07-02T13:51:58Z
dc.date.available2015-07-02T13:51:58Z
dc.date.issued2009-09-01
dc.identifier.citationStankiewicz , E , Kudahetti , S C , Prowse , D M , Ktori , E , Cuzick , J , Ambroisine , L , Zhang , X , Watkin , N , Corbishley , C & Berney , D M 2009 , ' HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis ' , Modern Pathology , vol. 22 , no. 9 , pp. 1160-1168 . https://doi.org/10.1038/modpathol.2009.77
dc.identifier.issn0893-3952
dc.identifier.otherPURE: 8695155
dc.identifier.otherPURE UUID: 557dbe79-6b78-48b8-8c0b-533fba5106af
dc.identifier.otherScopus: 69549116612
dc.identifier.otherPubMed: 19465901
dc.identifier.urihttp://hdl.handle.net/2299/16127
dc.description.abstractPenile verrucous carcinoma is a rare disease and little is known of its aetiology or pathogenesis. In this study we examined cell-cycle proteins expression and correlation with human papillomavirus infection in a series of 15 pure penile verrucous carcinomas from a single centre. Of 148 penile tumours, 15 (10%) were diagnosed as pure verrucous carcinomas. The expression of the cell-cycle-associated proteins p53, p21, RB, p16INK4A and Ki67 were examined by immunohistochemistry. Human papillomavirus infection was determined by polymerase chain reaction to identify a wide range of virus types. The expression of p16INK4A and Ki67 was significantly lower in verrucous carcinoma than in usual type squamous cell carcinoma, whereas the expression of p53, p21 and RB was not significantly different. p53 showed basal expression in contrast to usual type squamous cell carcinoma. Human papillomavirus infection was present in only 3 out of 13 verrucous carcinomas. Unique low-risk, high-risk and mixed viral infections were observed in each of the three cases. In conclusion, lower levels of p16INK4A and Ki67 expressions differentiate penile verrucous carcinoma from usual type squamous cell carcinoma. The low Ki67 index reflects the slow-growing nature of verrucous tumours. The low level of p16INK4A expression and human papillomavirus detection suggests that penile verrucous carcinoma pathogenesis is unrelated to human papillomavirus infection and the oncogenes and tumour suppressor genes classically altered by virus infection.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofModern Pathology
dc.rightsOpen
dc.subjectHuman papillomavirus
dc.subjectp16 INK4A
dc.subjectp21
dc.subjectp53
dc.subjectPenile verrucous carcinoma
dc.subjectRB
dc.titleHPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penisen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2009-09-01
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1038/modpathol.2009.77
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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