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dc.contributor.authorGao, Jing
dc.contributor.authorZhang, Xiaochen
dc.contributor.authorYu, Mei
dc.contributor.authorRen, Guogang
dc.contributor.authorYang, Zhuo
dc.date.accessioned2015-09-08T07:28:41Z
dc.date.available2015-09-08T07:28:41Z
dc.date.issued2015-11-04
dc.identifier.citationGao , J , Zhang , X , Yu , M , Ren , G & Yang , Z 2015 , ' Cognitive deficits induced by multi-walled carbon nanotubes via the autophagic pathway ' , Toxicology , vol. 337 , pp. 21-29 . https://doi.org/10.1016/j.tox.2015.08.011
dc.identifier.issn0300-483X
dc.identifier.otherPURE: 9194543
dc.identifier.otherPURE UUID: 492eb8dd-8110-4c3d-b292-25b056c0d5d1
dc.identifier.otherPubMed: 26327526
dc.identifier.otherScopus: 84941090359
dc.identifier.otherORCID: /0000-0001-8865-1526/work/32373240
dc.identifier.urihttp://hdl.handle.net/2299/16391
dc.descriptionThis document is the Accepted Manuscript version, made available under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License CC BY NC-ND 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
dc.description.abstractMulti-walled carbon nanotubes (MWCNTs) have shown potential applications in many fields, especially in the field of biomedicine. Several studies have reported that MWCNTs induce apoptosis and oxidative damage in nerve cells during in vitro experiments. However, there are few studies focused on the neurotoxicity of MWCNTs used in vivo. Many studies have reported that autophagy, a cellular stress response to degrade damaged cell components, can be activated by diverse nanoparticles. In this study, we investigated the neurotoxic effects of MWCNTs on hippocampal synaptic plasticity and spatial cognition in rats. Then, we used an inhibitor of autophagy called chloroquine (CQ) to examine whether autophagy plays an important role in hippocampal synaptic plasticity, since this was damaged by MWCNTs. In this study, adult male Wister rats were randomly divided into three groups: a control group, a group treated with MWCNTs (2.5mg/kg/day) and a group treated with MWCNTs+CQ (20mg/kg/day). After two-weeks of intraperitoneal (i.p.) injections, rats were subjected to the Morris water maze (MWM) test, and the long-term potentiation (LTP) and other biochemical parameters were determined. Results showed that MWCNTs could induce cognitive deficits, histopathological alteration and changes of autophagy level (increased the ratio of LC3 II /LC3 I and the expression of Beclin-1). Furthermore, we found that CQ could suppress MWCNTs-induced autophagic flux and partly rescue the synapse deficits, which occurred with the down-regulation of NR2B (a subunit of NMDA receptor) and synaptophysin (SYP) in the hippocampus. Our results suggest that MWCNTs could induce cognitive deficits in vivo via the increased autophagic levels, and provide a potential strategy to avoid the adverse effects of MWCNTs.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofToxicology
dc.rightsEmbargoed
dc.subjectMWCNTs
dc.subjectCognitive deficits
dc.subjectAutophag
dc.subjectChloroquine
dc.subjectRats
dc.subjectNanoparticles
dc.subjecttoxicity
dc.subjectNeuroscience(all)
dc.subjectMaterials Science(all)
dc.subjectMedicine(all)
dc.subjectHealth Professions(all)
dc.titleCognitive deficits induced by multi-walled carbon nanotubes via the autophagic pathwayen
dc.contributor.institutionSchool of Engineering and Technology
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionMaterials and Structures
dc.description.statusPeer reviewed
dc.date.embargoedUntil2016-08-30
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2015-11-04
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.tox.2015.08.011
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeEmbargoed


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