Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing
Cook, Michael T.
Smith, Sarah L.
Khutoryanskiy, Vitaliy V.
Glycopolymer hydrogels capable of mimicking mucosal tissue in mucoadhesion testing have been designed. Liquid formulations containing mucoadhesive polymers were found to be retained on these tissues to the same extent as ex vivo gastric mucosa, when using a dynamic method of assessing mucoadhesion