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dc.contributor.authorTorben-Nielsen, Ben
dc.contributor.authorSegev, Idan
dc.contributor.authorYarom, Yosef
dc.date.accessioned2016-03-07T09:57:35Z
dc.date.available2016-03-07T09:57:35Z
dc.date.issued2012
dc.identifier.citationTorben-Nielsen , B , Segev , I & Yarom , Y 2012 , ' The generation of phase differences and frequency changes in a network model of inferior olive subthreshold oscillations ' , PLoS Computational Biology , vol. 8 , no. 7 , e1002580 . https://doi.org/10.1371/journal.pcbi.1002580
dc.identifier.issn1553-734X
dc.identifier.otherPURE: 9331157
dc.identifier.otherPURE UUID: 56e25fbe-2ddd-4ff5-b9c3-098e245d5fc8
dc.identifier.otherPubMed: 22792054
dc.identifier.otherScopus: 84864585475
dc.identifier.urihttp://hdl.handle.net/2299/16724
dc.descriptionThis is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication
dc.description.abstractIt is commonly accepted that the Inferior Olive (IO) provides a timing signal to the cerebellum. Stable subthreshold oscillations in the IO can facilitate accurate timing by phase-locking spikes to the peaks of the oscillation. Several theoretical models accounting for the synchronized subthreshold oscillations have been proposed, however, two experimental observations remain an enigma. The first is the observation of frequent alterations in the frequency of the oscillations. The second is the observation of constant phase differences between simultaneously recorded neurons. In order to account for these two observations we constructed a canonical network model based on anatomical and physiological data from the IO. The constructed network is characterized by clustering of neurons with similar conductance densities, and by electrical coupling between neurons. Neurons inside a cluster are densely connected with weak strengths, while neurons belonging to different clusters are sparsely connected with stronger connections. We found that this type of network can robustly display stable subthreshold oscillations. The overall frequency of the network changes with the strength of the inter-cluster connections, and phase differences occur between neurons of different clusters. Moreover, the phase differences provide a mechanistic explanation for the experimentally observed propagating waves of activity in the IO. We conclude that the architecture of the network of electrically coupled neurons in combination with modulation of the inter-cluster coupling strengths can account for the experimentally observed frequency changes and the phase differences.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofPLoS Computational Biology
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.subjectAnimals
dc.subjectCalcium
dc.subjectComputer Simulation
dc.subjectModels, Neurological
dc.subjectNeurons
dc.subjectOlivary Nucleus
dc.titleThe generation of phase differences and frequency changes in a network model of inferior olive subthreshold oscillationsen
dc.contributor.institutionSchool of Computer Science
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Computer Science
dc.description.versiontypeFinal Published version
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1371/journal.pcbi.1002580
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeopenAccess


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