Show simple item record

A sex-linked Ace gene, not linked to insensitive acetylcholinesterase-mediated insecticide resistance in Culex pipiens

dc.contributor.authorMalcolm, Colin
dc.contributor.authorBourguet, D.
dc.contributor.authorAscolillo, A.
dc.contributor.authorRooker, S. J.
dc.contributor.authorGarvey, C. F.
dc.contributor.authorHall, L. M.
dc.contributor.authorPasteur, N.
dc.contributor.authorRaymond, M.
dc.date.accessioned2016-03-07T09:57:49Z
dc.date.available2016-03-07T09:57:49Z
dc.date.issued1998-05
dc.identifier.citationMalcolm , C , Bourguet , D , Ascolillo , A , Rooker , S J , Garvey , C F , Hall , L M , Pasteur , N & Raymond , M 1998 , ' A sex-linked Ace gene, not linked to insensitive acetylcholinesterase-mediated insecticide resistance in Culex pipiens ' , Insect Molecular Biology , vol. 7 , no. 2 , pp. 107-120 . https://doi.org/10.1046/j.1365-2583.1998.72055.x
dc.identifier.issn0962-1075
dc.identifier.urihttp://hdl.handle.net/2299/16727
dc.description.abstractAn acetylcholinesterase (AChE) gene, Ace.x, showing 93% identity of deduced amino acid sequence to Anopheles stephensi Ace has been cloned from a Culex pipiens strain homozygous for insensitive AChE (iAChE) mediated insecticide resistance. DNA sequence of genomic DNA clones identified exons 2-5. RFLP of six clones indicated four possible alleles. Linkage analysis located Ace.x to chromosome I, less than 0.8 centimorgans from the sex locus, whereas the locus conferring resistance was 2.0 centimorgans from plum-eye on chromosome II. Ace.1 coding for AChE1, which is associated with resistance, is therefore autosomal. We propose that Ace.x is the recently postulated Ace.2 coding for the biochemically distinct AChE2, which is not associated with resistance.en
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofInsect Molecular Biology
dc.subjectAcetylcholinesterase
dc.subjectAmino Acid Sequence
dc.subjectAnimals
dc.subjectBase Sequence
dc.subjectCulex
dc.subjectDNA, Complementary
dc.subjectFemale
dc.subjectHumans
dc.subjectInsecticide Resistance
dc.subjectMale
dc.subjectMolecular Sequence Data
dc.subjectSequence Analysis, DNA
dc.subjectSequence Homology, Amino Acid
dc.subjectSex Factors
dc.titleA sex-linked Ace gene, not linked to insensitive acetylcholinesterase-mediated insecticide resistance in Culex pipiensen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionBiosciences Research Group
dc.contributor.institutionCentre for Research in Mechanisms of Disease and Drug Discovery
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionCrop Protection and Climate Change
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.contributor.institutionCentre for Agriculture, Food and Environmental Management Research
dc.contributor.institutionCentre for Future Societies Research
dc.description.statusPeer reviewed
rioxxterms.versionofrecord10.1046/j.1365-2583.1998.72055.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record