dc.contributor.author | Laudanski, Jonathan | |
dc.contributor.author | Torben-Nielsen, Ben | |
dc.contributor.author | Segev, Idan | |
dc.contributor.author | Shamma, Shihab | |
dc.date.accessioned | 2016-03-08T11:43:25Z | |
dc.date.available | 2016-03-08T11:43:25Z | |
dc.date.issued | 2014-08 | |
dc.identifier.citation | Laudanski , J , Torben-Nielsen , B , Segev , I & Shamma , S 2014 , ' Spatially distributed dendritic resonance selectively filters synaptic input ' , PLoS Computational Biology , vol. 10 , no. 8 , e1003775 . https://doi.org/10.1371/journal.pcbi.1003775 | |
dc.identifier.issn | 1553-734X | |
dc.identifier.uri | http://hdl.handle.net/2299/16735 | |
dc.description | © 2014 Laudanski et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.description.abstract | An important task performed by a neuron is the selection of relevant inputs from among thousands of synapses impinging on the dendritic tree. Synaptic plasticity enables this by strenghtening a subset of synapses that are, presumably, functionally relevant to the neuron. A different selection mechanism exploits the resonance of the dendritic membranes to preferentially filter synaptic inputs based on their temporal rates. A widely held view is that a neuron has one resonant frequency and thus can pass through one rate. Here we demonstrate through mathematical analyses and numerical simulations that dendritic resonance is inevitably a spatially distributed property; and therefore the resonance frequency varies along the dendrites, and thus endows neurons with a powerful spatiotemporal selection mechanism that is sensitive both to the dendritic location and the temporal structure of the incoming synaptic inputs. | en |
dc.format.extent | 10 | |
dc.format.extent | 2418321 | |
dc.language.iso | eng | |
dc.relation.ispartof | PLoS Computational Biology | |
dc.subject | Computational Biology | |
dc.subject | Dendrites | |
dc.subject | Ion Channels | |
dc.subject | Models, Neurological | |
dc.subject | Neuronal Plasticity | |
dc.subject | Neurons | |
dc.subject | Synapses | |
dc.title | Spatially distributed dendritic resonance selectively filters synaptic input | en |
dc.contributor.institution | School of Computer Science | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1371/journal.pcbi.1003775 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |