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dc.contributor.authorSudhakar, Shyam Kumar
dc.contributor.authorTorben-Nielsen, Ben
dc.contributor.authorDe Schutter, Erik
dc.date.accessioned2016-03-21T09:35:34Z
dc.date.available2016-03-21T09:35:34Z
dc.date.issued2015-12-02
dc.identifier.citationSudhakar , S K , Torben-Nielsen , B & De Schutter , E 2015 , ' Cerebellar Nuclear Neurons Use Time and Rate Coding to Transmit Purkinje Neuron Pauses ' , PLoS Computational Biology , vol. 11 , no. 12 , e1004641 . https://doi.org/10.1371/journal.pcbi.1004641
dc.identifier.issn1553-734X
dc.identifier.otherPURE: 9573964
dc.identifier.otherPURE UUID: 970ad991-ffb1-483a-ac3f-90f7d4cbdd1d
dc.identifier.otherPubMed: 26630202
dc.identifier.otherScopus: 84953240420
dc.identifier.urihttp://hdl.handle.net/2299/16841
dc.descriptionCopyright: © 2015 Sudhakar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.description.abstractNeurons of the cerebellar nuclei convey the final output of the cerebellum to their targets in various parts of the brain. Within the cerebellum their direct upstream connections originate from inhibitory Purkinje neurons. Purkinje neurons have a complex firing pattern of regular spikes interrupted by intermittent pauses of variable length. How can the cerebellar nucleus process this complex input pattern? In this modeling study, we investigate different forms of Purkinje neuron simple spike pause synchrony and its influence on candidate coding strategies in the cerebellar nuclei. That is, we investigate how different alignments of synchronous pauses in synthetic Purkinje neuron spike trains affect either time-locking or rate-changes in the downstream nuclei. We find that Purkinje neuron synchrony is mainly represented by changes in the firing rate of cerebellar nuclei neurons. Pause beginning synchronization produced a unique effect on nuclei neuron firing, while the effect of pause ending and pause overlapping synchronization could not be distinguished from each other. Pause beginning synchronization produced better time-locking of nuclear neurons for short length pauses. We also characterize the effect of pause length and spike jitter on the nuclear neuron firing. Additionally, we find that the rate of rebound responses in nuclear neurons after a synchronous pause is controlled by the firing rate of Purkinje neurons preceding it.en
dc.language.isoeng
dc.relation.ispartofPLoS Computational Biology
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.titleCerebellar Nuclear Neurons Use Time and Rate Coding to Transmit Purkinje Neuron Pausesen
dc.contributor.institutionSchool of Computer Science
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Computer Science
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2015-11-03
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1371/journal.pcbi.1004641
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeopenAccess


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