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        Mucoadhesion and mucosa-mimetic materials - a mini-review

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        Mucoadhesion_and_mucosa_mimetic_materials_Cook_and_Khutoryanskiy.pdf (PDF, 779Kb)
        Author
        Cook, Michael T.
        Khutoryanskiy, Vitaliy V.
        Attention
        2299/16856
        Abstract
        Mucoadhesion describes an attractive interaction between dosage form and mucosal membrane. The evaluation of mucoadhesive excipients often requires the use of ex vivo mucosal tissues taken from laboratory animals. These can be difficult to source, highly heterogeneous, and require the use of animal products. Thus, from both a user-convenience and ethical point-of-view, it is desirable to produce a synthetic alternative to these tissues - a mucosa-mimetic material. In this mini-review, the use of alternative materials to test the performance of mucoadhesives is reviewed and discussed. There is a surprising prevalence of the use of mucosa-mimics in the literature, which hitherto has not been compiled and compared.
        Publication date
        2015-11-30
        Published in
        International Journal of Pharmaceutics
        Published version
        https://doi.org/10.1016/j.ijpharm.2015.09.064
        Other links
        http://hdl.handle.net/2299/16856
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