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dc.contributor.authorDuncanson, Philip
dc.contributor.authorCheong, Yuen-Ki
dc.contributor.authorMotevalli, Majid
dc.contributor.authorGriffiths, D. Vaughan
dc.date.accessioned2016-04-07T11:41:04Z
dc.date.available2016-04-07T11:41:04Z
dc.date.issued2012
dc.identifier.citationDuncanson , P , Cheong , Y-K , Motevalli , M & Griffiths , D V 2012 , ' A novel approach to isoindolo[2,1-a]indol-6-ones ' , Organic & Biomolecular Chemistry , vol. 10 , no. 21 , pp. 4266-4279 . https://doi.org/10.1039/C2OB25314C
dc.identifier.issn1477-0520
dc.identifier.otherPURE: 9775887
dc.identifier.otherPURE UUID: 14e79eca-330e-4d48-9908-3c79ed146084
dc.identifier.otherRIS: urn:ECCFE7D49A9FB11A81F2EF8BB4F815BB
dc.identifier.otherScopus: 84861879231
dc.identifier.urihttp://hdl.handle.net/2299/17060
dc.description.abstractA convenient route to isoindolo[2,1-a]indol-6-ones has been developed starting from the appropriate 2-(N-phthaloyl)benzoic acids. Formation of the acid chlorides with thionyl chloride followed by heating with triethyl phosphite in a suitable solvent resulted in a multistep reaction giving tetracyclic [small beta]-ketophosphonates that on reduction with sodium borohydride gave the required indolones in good overall yields. Analogous [small beta]-ketophosphonates were also prepared starting with N,N-(1,8-naphthaloyl)-2-aminobenzoic acid and 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acids although of these only the naphthaloyl product could be reduced with sodium borohydride without cleaving the amide bond in the ring system.en
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofOrganic & Biomolecular Chemistry
dc.titleA novel approach to isoindolo[2,1-a]indol-6-onesen
dc.contributor.institutionMaterials and Structures
dc.contributor.institutionSchool of Physics, Engineering & Computer Science
dc.contributor.institutionDepartment of Engineering and Technology
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionBioEngineering
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1039/C2OB25314C
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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