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        Physical stabilization of low-molecular-weight amorphous drugs in the solid state : a material science approach

        Author
        Qi, Sheng
        McAuley, William J.
        Yang, Ziyi
        Tipduangta, Pratchaya
        Attention
        2299/17122
        Abstract
        Use of the amorphous state is considered to be one of the most effective approaches for improving the dissolution and subsequent oral bioavailability of poorly water-soluble drugs. However as the amorphous state has much higher physical instability in comparison with its crystalline counterpart, stabilization of amorphous drugs in a solid-dosage form presents a major challenge to formulators. The currently used approaches for stabilizing amorphous drug are discussed in this article with respect to their preparation, mechanism of stabilization and limitations. In order to realize the potential of amorphous formulations, significant efforts are required to enable the prediction of formulation performance. This will facilitate the development of computational tools that can inform a rapid and rational formulation development process for amorphous drugs.
        Publication date
        2014-07
        Published in
        Therapeutic Delivery
        Published version
        https://doi.org/10.4155/tde.14.39
        Other links
        http://hdl.handle.net/2299/17122
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