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dc.contributor.authorMohamed, Nura A.
dc.contributor.authorAhmetaj-Shala, Blerina
dc.contributor.authorDuluc, Lucie
dc.contributor.authorMackenzie, Louise S.
dc.contributor.authorKirkby, Nicholas S.
dc.contributor.authorReed, Daniel M.
dc.contributor.authorLickiss, Paul D.
dc.contributor.authorDavies, Robert P.
dc.contributor.authorFreeman, Gemma R.
dc.contributor.authorWojciak-Stothard, Beata
dc.contributor.authorChester, Adrian H.
dc.contributor.authorEl-Sherbiny, Ibrahim M.
dc.contributor.authorMitchell, Jane A.
dc.contributor.authorYacoub, Magdi H.
dc.date.accessioned2016-04-27T11:09:31Z
dc.date.available2016-04-27T11:09:31Z
dc.date.issued2016-04
dc.identifier.citationMohamed , N A , Ahmetaj-Shala , B , Duluc , L , Mackenzie , L S , Kirkby , N S , Reed , D M , Lickiss , P D , Davies , R P , Freeman , G R , Wojciak-Stothard , B , Chester , A H , El-Sherbiny , I M , Mitchell , J A & Yacoub , M H 2016 , ' A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension ' , Journal of Cardiovascular Translational Research , vol. 9 , no. 2 , pp. 162-164 . https://doi.org/10.1007/s12265-016-9684-2
dc.identifier.issn1937-5395
dc.identifier.otherPURE: 9986646
dc.identifier.otherPURE UUID: 37031a67-904a-42e7-998a-db96e92610f3
dc.identifier.otherPubMed: 26960567
dc.identifier.otherScopus: 84960124312
dc.identifier.urihttp://hdl.handle.net/2299/17140
dc.descriptionCopyright The Author(s) 2016. This article is published with open access at Springerlink.com. Open Access - This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
dc.description.abstractPulmonary arterial hypertension (PAH) is a chronic and progressive disease which continues to carry an unacceptably high mortality and morbidity. The nitric oxide (NO) pathway has been implicated in the pathophysiology and progression of the disease. Its extremely short half-life and systemic effects have hampered the clinical use of NO in PAH. In an attempt to circumvent these major limitations, we have developed a new NO-nanomedicine formulation. The formulation was based on hydrogel-like polymeric composite NO-releasing nanoparticles (NO-RP). The kinetics of NO release from the NO-RP showed a peak at about 120 min followed by a sustained release for over 8 h. The NO-RP did not affect the viability or inflammation responses of endothelial cells. The NO-RP produced concentration-dependent relaxations of pulmonary arteries in mice with PAH induced by hypoxia. In conclusion, NO-RP drugs could considerably enhance the therapeutic potential of NO therapy for PAH.en
dc.language.isoeng
dc.relation.ispartofJournal of Cardiovascular Translational Research
dc.rightsOpen
dc.titleA New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertensionen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.contributor.institutionCardiovascular Pathologies
dc.contributor.institutionDiabetic neuropathies
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionBasic and Clinical Science Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2016-04
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1007/s12265-016-9684-2
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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