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dc.contributor.authorLi, Longfei
dc.contributor.authorChen, Lin
dc.contributor.authorZhang, Huan
dc.contributor.authorYang, Yongzhen
dc.contributor.authorLiu, Xuguang
dc.contributor.authorChen, Yong
dc.date.accessioned2016-04-27T11:09:33Z
dc.date.available2016-04-27T11:09:33Z
dc.date.issued2016-04-01
dc.identifier.citationLi , L , Chen , L , Zhang , H , Yang , Y , Liu , X & Chen , Y 2016 , ' Temperature and magnetism bi-responsive molecularly imprinted polymers: Preparation, adsorption mechanism and properties as drug delivery system for sustained release of 5-fluorouracil ' , Materials Science and Engineering C , vol. 61 , pp. 158-168 . https://doi.org/10.1016/j.msec.2015.12.027
dc.identifier.issn0928-4931
dc.identifier.otherPURE: 9987532
dc.identifier.otherPURE UUID: 87e0993c-61be-4f8d-95fa-f64362b8fb44
dc.identifier.otherScopus: 84951064788
dc.identifier.urihttp://hdl.handle.net/2299/17141
dc.descriptionThis document is the Accepted Manuscript version of the following article: Longfei Li, Lin Chen, Huan Zhang, Yongshen Yang, Xuguang Liu, and Yongkang Chen, ‘Temperature and magnetism bi-responsive molecularly imprinted polymers: Preparation, adsorption mechanism and properties as drug delivery system for sustained release of 5-fluorouracil’, Materials Science and Engineering: C, Vol. 61: 158-168, April 2016, made available under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License CC BY NC-ND 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.description.abstractTemperature and magnetism bi-responsive molecularly imprinted polymers (TMMIPs) based on Fe3O4-encapsulating carbon nanospheres were prepared by free radical polymerization, and applied to selective adsorption and controlled release of 5-fluorouracil (5-FU) from an aqueous solution. Characterization results show that the as-synthesized TMMIPs have an average diameter of about 150 nm with a typical core–shell structure, and the thickness of the coating layer is approximately 50 nm. TMMIPs also displayed obvious magnetic properties and thermo-sensitivity. The adsorption results show that the prepared TMMIPs exhibit good adsorption capacity (up to 96.53 mg/g at 25 °C) and recognition towards 5-FU. The studies on 5-FU loading and release in vitro suggest that the release rate increases with increasing temperature. Meanwhile, adsorption mechanisms were explored by using a computational analysis to simulate the imprinted site towards 5-FU. The interaction energy between the imprinted site and 5-FU is − 112.24 kJ/mol, originating from a hydrogen bond, Van der Waals forces and a hydrophobic interaction between functional groups located on 5-FU and a NIPAM monomer. The electrostatic potential charges and population analysis results suggest that the imprinted site of 5-FU can be introduced on the surface of TMMIPs, confirming their selective adsorption behavior for 5-FU.en
dc.format.extent11
dc.language.isoeng
dc.relation.ispartofMaterials Science and Engineering C
dc.subjectMolecular imprinting technique
dc.subjectTemperature-sensitivity
dc.subjectMagnetism
dc.subjectDrug delivery system
dc.subjectSimulate
dc.subjectImprinted site
dc.titleTemperature and magnetism bi-responsive molecularly imprinted polymers: Preparation, adsorption mechanism and properties as drug delivery system for sustained release of 5-fluorouracilen
dc.contributor.institutionSchool of Engineering and Technology
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionSustainable Energy Technologies
dc.description.statusPeer reviewed
dc.date.embargoedUntil2016-12-16
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.msec.2015.12.027
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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