dc.contributor.author | Wong, Jonathan | |
dc.contributor.author | Sridharan, Sivakumar | |
dc.contributor.author | Berdeprado, Jocelyn | |
dc.contributor.author | Viljoen, Adie | |
dc.contributor.author | Vilar Hall, Enric | |
dc.contributor.author | Wellsted, David | |
dc.contributor.author | Farrington, Kenneth | |
dc.date.accessioned | 2016-05-26T10:26:20Z | |
dc.date.available | 2016-05-26T10:26:20Z | |
dc.date.issued | 2016-02-16 | |
dc.identifier.citation | Wong , J , Sridharan , S , Berdeprado , J , Viljoen , A , Vilar Hall , E , Wellsted , D & Farrington , K 2016 , ' Predicting residual kidney function in hemodialysis patients using serum β-trace protein and β2-microglobulin ' , Kidney International , vol. 89 , no. 5 , pp. 1090-1098 . https://doi.org/10.1016/j.kint.2015.12.042 | |
dc.identifier.issn | 0085-2538 | |
dc.identifier.uri | http://hdl.handle.net/2299/17204 | |
dc.description | Copyright 2016, International Society of Nephrology. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |
dc.description.abstract | Residual kidney function (RKF) contributes significant solute clearance in hemodialysis patients. Kidney Diseases Outcomes Quality Initiative (KDOQI) guidelines suggest that hemodialysis dose can be safely reduced in those with residual urea clearance (KRU) of 2 ml/min/1.73 m(2) or more. However, serial measurement of RKF is cumbersome and requires regular interdialytic urine collections. Simpler methods for assessing RKF are needed. β-trace protein (βTP) and β2-microglobulin (β2M) have been proposed as alternative markers of RKF. We derived predictive equations to estimate glomerular filtration rate (GFR) and KRU based on serum βTP and β2M from 191 hemodialysis patients based on standard measurements of KRU and GFR (mean of urea and creatinine clearances) using interdialytic urine collections. These modeled equations were tested in a separate validation cohort of 40 patients. A prediction equation for GFR that includes both βTP and β2M provided a better estimate than either alone and contained the terms 1/βTP, 1/β2M, 1/serum creatinine, and a factor for gender. The equation for KRU contained the terms 1/βTP, 1/β2M, and a factor for ethnicity. Mean bias between predicted and measured GFR was 0.63 ml/min and 0.50 ml/min for KRU. There was substantial agreement between predicted and measured KRU at a cut-off level of 2 ml/min/1.73 m(2). Thus, equations involving βTP and β2M provide reasonable estimates of RKF and could potentially be used to identify those with KRU of 2 ml/min/1.73 m(2) or more to follow the KDOQI incremental hemodialysis algorithm. | en |
dc.format.extent | 304183 | |
dc.language.iso | eng | |
dc.relation.ispartof | Kidney International | |
dc.title | Predicting residual kidney function in hemodialysis patients using serum β-trace protein and β2-microglobulin | en |
dc.contributor.institution | Psychology | |
dc.contributor.institution | Centre for Lifespan and Chronic Illness Research | |
dc.contributor.institution | Health and Clinical Psychology Research Group | |
dc.contributor.institution | Health Services and Medicine | |
dc.contributor.institution | Behaviour Change in Health and Business | |
dc.contributor.institution | Department of Psychology and Sports Sciences | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Health Research Methods Unit | |
dc.contributor.institution | Centre for Research in Psychology and Sports | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | Basic and Clinical Science Unit | |
dc.contributor.institution | Postgraduate Medicine | |
dc.contributor.institution | Pharmacology and Clinical Science Research | |
dc.contributor.institution | Department of Pharmacy, Pharmacology and Postgraduate Medicine | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1016/j.kint.2015.12.042 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |