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dc.contributor.authorFilippov, Sergey K
dc.contributor.authorBogomolova, Anna Yurevna
dc.contributor.authorKaberov, Leonid
dc.contributor.authorVelychkivska, Nadiia
dc.contributor.authorStarovoytova, Larisa
dc.contributor.authorCernochova, Zulfiya
dc.contributor.authorRogers, Sarah E
dc.contributor.authorLau, Wing Man
dc.contributor.authorKhutoryanskiy, Vitaliy V
dc.contributor.authorCook, Michael T
dc.date.accessioned2016-11-30T18:13:02Z
dc.date.available2016-11-30T18:13:02Z
dc.date.issued2016-05-09
dc.identifier.citationFilippov , S K , Bogomolova , A Y , Kaberov , L , Velychkivska , N , Starovoytova , L , Cernochova , Z , Rogers , S E , Lau , W M , Khutoryanskiy , V V & Cook , M T 2016 , ' Internal nanoparticle structure of temperature-responsive self-assembled PNIPAM-b-PEG-b-PNIPAM triblock copolymers in aqueous solutions : NMR, SANS and Light Scattering studies ' , Langmuir : the ACS journal of surfaces and colloids , vol. 32 , no. 21 , pp. 5314-5323 . https://doi.org/10.1021/acs.langmuir.6b00284
dc.identifier.issn0743-7463
dc.identifier.otherPURE: 10161674
dc.identifier.otherPURE UUID: 6589b2ed-58f0-4eb6-bd1c-dc95c9d408dd
dc.identifier.otherPubMed: 27159129
dc.identifier.otherScopus: 84973345069
dc.identifier.urihttp://hdl.handle.net/2299/17369
dc.descriptionThis is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
dc.description.abstractIn this study we report detailed information on the internal structure of PNIPAM-b-PEG-b-PNIPAM nanoparticles formed from self-assembly in aqueous solutions upon increase in temperature. NMR spectroscopy, light scattering and small-angle neutron scattering (SANS) were used to monitor different stages of nanoparticle formation as a function of temperature, providing insight into the fundamental processes involved. The presence of PEG in a copolymer structure significantly affects the formation of nanoparticles, making their transition to occur over a broader temperature range. The crucial parameter that controls the transition is the ratio of PEG/PNIPAM. For pure PNIPAM, the transition is sharp; the higher the PEG/PNIPAM ratio results in a broader transition. This behavior is explained by different mechanisms of PNIPAM block incorporation during nanoparticle formation at different PEG/PNIPAM ratios. Contrast variation experiments using SANS show that the structure of nanoparticles above cloud point temperatures for PNIPAM-b-PEG-b-PNIPAM copolymers is drastically different from the structure of PNIPAM mesoglobules. In contrast with pure PNIPAM mesoglobules, where solid-like particles and chain network with a mesh size of 1-3 nm are present; nanoparticles formed from PNIPAM-b-PEG-b-PNIPAM copolymers have non-uniform structure with "frozen" areas interconnected by single chains in Gaussian conformation. SANS data with deuterated "invisible" PEG blocks imply that PEG is uniformly distributed inside of a nanoparticle. It is kinetically flexible PEG blocks which affect the nanoparticle formation by prevention of PNIPAM microphase separation.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofLangmuir : the ACS journal of surfaces and colloids
dc.rightsOpen
dc.titleInternal nanoparticle structure of temperature-responsive self-assembled PNIPAM-b-PEG-b-PNIPAM triblock copolymers in aqueous solutions : NMR, SANS and Light Scattering studiesen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2016-05-09
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1021/acs.langmuir.6b00284
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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