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dc.contributor.authorFilippov, Sergey K
dc.contributor.authorBogomolova, Anna Yurevna
dc.contributor.authorKaberov, Leonid
dc.contributor.authorVelychkivska, Nadiia
dc.contributor.authorStarovoytova, Larisa
dc.contributor.authorCernochova, Zulfiya
dc.contributor.authorRogers, Sarah E
dc.contributor.authorLau, Wing Man
dc.contributor.authorKhutoryanskiy, Vitaliy V
dc.contributor.authorCook, Michael T
dc.date.accessioned2016-11-30T18:13:02Z
dc.date.available2016-11-30T18:13:02Z
dc.date.issued2016-05-09
dc.identifier.citationFilippov , S K , Bogomolova , A Y , Kaberov , L , Velychkivska , N , Starovoytova , L , Cernochova , Z , Rogers , S E , Lau , W M , Khutoryanskiy , V V & Cook , M T 2016 , ' Internal nanoparticle structure of temperature-responsive self-assembled PNIPAM-b-PEG-b-PNIPAM triblock copolymers in aqueous solutions : NMR, SANS and Light Scattering studies ' , Langmuir : the ACS journal of surfaces and colloids , vol. 32 , no. 21 , pp. 5314-5323 . https://doi.org/10.1021/acs.langmuir.6b00284
dc.identifier.issn0743-7463
dc.identifier.urihttp://hdl.handle.net/2299/17369
dc.descriptionThis is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
dc.description.abstractIn this study we report detailed information on the internal structure of PNIPAM-b-PEG-b-PNIPAM nanoparticles formed from self-assembly in aqueous solutions upon increase in temperature. NMR spectroscopy, light scattering and small-angle neutron scattering (SANS) were used to monitor different stages of nanoparticle formation as a function of temperature, providing insight into the fundamental processes involved. The presence of PEG in a copolymer structure significantly affects the formation of nanoparticles, making their transition to occur over a broader temperature range. The crucial parameter that controls the transition is the ratio of PEG/PNIPAM. For pure PNIPAM, the transition is sharp; the higher the PEG/PNIPAM ratio results in a broader transition. This behavior is explained by different mechanisms of PNIPAM block incorporation during nanoparticle formation at different PEG/PNIPAM ratios. Contrast variation experiments using SANS show that the structure of nanoparticles above cloud point temperatures for PNIPAM-b-PEG-b-PNIPAM copolymers is drastically different from the structure of PNIPAM mesoglobules. In contrast with pure PNIPAM mesoglobules, where solid-like particles and chain network with a mesh size of 1-3 nm are present; nanoparticles formed from PNIPAM-b-PEG-b-PNIPAM copolymers have non-uniform structure with "frozen" areas interconnected by single chains in Gaussian conformation. SANS data with deuterated "invisible" PEG blocks imply that PEG is uniformly distributed inside of a nanoparticle. It is kinetically flexible PEG blocks which affect the nanoparticle formation by prevention of PNIPAM microphase separation.en
dc.format.extent10
dc.format.extent597468
dc.language.isoeng
dc.relation.ispartofLangmuir : the ACS journal of surfaces and colloids
dc.titleInternal nanoparticle structure of temperature-responsive self-assembled PNIPAM-b-PEG-b-PNIPAM triblock copolymers in aqueous solutions : NMR, SANS and Light Scattering studiesen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.description.statusPeer reviewed
rioxxterms.versionofrecord10.1021/acs.langmuir.6b00284
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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