Mechanisms contributing to visceral hypersensitivity : focus on splanchnic afferent nerve signalling
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Author
Deiteren, Annemie
de Man, Joris
Keating, Christopher
Jiang, Wen
de Schepper, Heiko
Pelckmans, Paul
Francque, Sven
de Winter, Benedicte
Attention
2299/17443
Abstract
Visceral hypersensitivity is a main characteristic of functional bowel disorders and is mediated by both peripheral and central factors. We investigated whether enhanced splanchnic afferent signaling in vitro is associated with visceral hypersensitivity in vivo in an acute and postinflammatory rat model of colitis.