Mechanisms contributing to visceral hypersensitivity : focus on splanchnic afferent nerve signalling
de Man, Joris
de Schepper, Heiko
de Winter, Benedicte
Visceral hypersensitivity is a main characteristic of functional bowel disorders and is mediated by both peripheral and central factors. We investigated whether enhanced splanchnic afferent signaling in vitro is associated with visceral hypersensitivity in vivo in an acute and postinflammatory rat model of colitis.