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dc.contributor.authorO'Donovan, Clare B
dc.contributor.authorWalsh, Marianne C
dc.contributor.authorForster, Hannah
dc.contributor.authorWoolhead, Clara
dc.contributor.authorCelis-Morales, Carlos
dc.contributor.authorFallaize, Rosalind
dc.contributor.authorMacready, Anna L
dc.contributor.authorMarsaux, Cyril F M
dc.contributor.authorNavas-Carretero, Santiago
dc.contributor.authorSan-Cristobal, Rodrigo
dc.contributor.authorKolossa, Silvia
dc.contributor.authorMavrogianni, Christina
dc.contributor.authorLambrinou, Christina P
dc.contributor.authorMoschonis, George
dc.contributor.authorGodlewska, Magdalena
dc.contributor.authorSurwillo, Agnieszka
dc.contributor.authorBouwman, Jildau
dc.contributor.authorGrimaldi, Keith
dc.contributor.authorTraczyk, Iwona
dc.contributor.authorDrevon, Christian A
dc.contributor.authorDaniel, Hannelore
dc.contributor.authorManios, Yannis
dc.contributor.authorMartinez, J Alfredo
dc.contributor.authorSaris, Wim H M
dc.contributor.authorLovegrove, Julie A
dc.contributor.authorMathers, John C
dc.contributor.authorGibney, Michael J
dc.contributor.authorBrennan, Lorraine
dc.contributor.authorGibney, Eileen R
dc.date.accessioned2016-12-19T18:10:00Z
dc.date.available2016-12-19T18:10:00Z
dc.date.issued2016-09-29
dc.identifier.citationO'Donovan , C B , Walsh , M C , Forster , H , Woolhead , C , Celis-Morales , C , Fallaize , R , Macready , A L , Marsaux , C F M , Navas-Carretero , S , San-Cristobal , R , Kolossa , S , Mavrogianni , C , Lambrinou , C P , Moschonis , G , Godlewska , M , Surwillo , A , Bouwman , J , Grimaldi , K , Traczyk , I , Drevon , C A , Daniel , H , Manios , Y , Martinez , J A , Saris , W H M , Lovegrove , J A , Mathers , J C , Gibney , M J , Brennan , L & Gibney , E R 2016 , ' The impact of MTHFR 677C → T risk knowledge on changes in folate intake : findings from the Food4Me study ' , Genes and Nutrition , vol. 11 , no. 25 , pp. 25 . https://doi.org/10.1186/s12263-016-0539-x
dc.identifier.issn1555-8932
dc.identifier.otherPURE: 10583221
dc.identifier.otherPURE UUID: 5b932cc0-7b9b-463a-ae77-40ea079cd019
dc.identifier.otherPubMed: 27708721
dc.identifier.urihttp://hdl.handle.net/2299/17454
dc.description© 2016 The Author(s). Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.description.abstractBACKGROUND: It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from the Food4Me study. This was a 6-month Internet-based randomised controlled trial conducted across seven centres in Europe where individuals received either general healthy eating advice or varying levels of personalised nutrition advice. Participants who received genotype-based personalised advice were informed whether they had the risk (CT/TT) (n = 178) or non-risk (CC) (n = 141) alleles of the methylenetetrahydrofolate reductase (MTHFR) gene in relation to cardiovascular health and the importance of a sufficient intake of folate. General linear model analysis was used to assess changes in folate intake between the MTHFR risk, MTHFR non-risk and control groups from baseline to month 6 of the intervention. RESULTS: There were no differences between the groups for age, gender or BMI. However, there was a significant difference in country distribution between the groups (p = 0.010). Baseline folate intakes were 412 ± 172, 391 ± 190 and 410 ± 186 μg per 10 MJ for the risk, non-risk and control groups, respectively. There were no significant differences between the three groups in terms of changes in folate intakes from baseline to month 6. Similarly, there were no changes in reported intake of food groups high in folate. CONCLUSIONS: These results suggest that knowledge of MTHFR 677C → T genotype did not improve folate intake in participants with the risk variant compared with those with the non-risk variant. TRIAL REGISTRATION: ClinicalTrials.gov NCT01530139.en
dc.language.isoeng
dc.relation.ispartofGenes and Nutrition
dc.rightsOpen
dc.subjectMTHFR
dc.subjectMethylenetetrahydrofolate reductase 677C
dc.subjectT genotype,
dc.subjectGenetic risk knowledge
dc.subjectFolate
dc.subjectPersonalised nutrition
dc.titleThe impact of MTHFR 677C → T risk knowledge on changes in folate intake : findings from the Food4Me studyen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.contributor.institutionWeight and Obesity Research Group
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2016-09-29
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1186/s12263-016-0539-x
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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