Show simple item record

dc.contributor.authorPritchard, Sara
dc.contributor.authorHikima, Atsuko
dc.contributor.authorJackson, Michael
dc.contributor.authorLione, Lisa
dc.contributor.authorBenham, Christopher
dc.contributor.authorChaudhuri, K. Ray
dc.contributor.authorRose, Sarah
dc.contributor.authorJenner, Peter
dc.contributor.authorIravani, Mahmoud
dc.date.accessioned2017-06-08T17:51:14Z
dc.date.available2017-06-08T17:51:14Z
dc.date.issued2017-05-17
dc.identifier.citationPritchard , S , Hikima , A , Jackson , M , Lione , L , Benham , C , Chaudhuri , K R , Rose , S , Jenner , P & Iravani , M 2017 , ' Altered detrusor contractility in MPTP-treated common marmosets with bladder hyperreflexia ' , PLoS ONE , vol. 12 , no. 5 , e0175797 . https://doi.org/10.1371/journal.pone.0175797
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 11387634
dc.identifier.otherPURE UUID: c68d9e5f-dfd1-4c66-8a90-7c40a950ec01
dc.identifier.otherPubMed: 28520722
dc.identifier.otherPubMedCentral: PMC5435136
dc.identifier.otherScopus: 85019879600
dc.identifier.urihttp://hdl.handle.net/2299/18313
dc.descriptionCopyright: © 2017 Pritchard et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.description.abstractBladder hyperreflexia is a common non-motor feature of Parkinson’s disease. We now report on the contractility of the isolated primate detrusor strips devoid of nerve input and show that following MPTP, the amplitude and frequency of spontaneous contraction was increased. These responses were unaffected by dopamine D1 and D2 receptor agonists A77636 and ropinirole respectively. Contractions by exogenous carbachol, histamine or ATP were similar and no differences in the magnitude of noradrenaline-induced relaxation were seen in detrusor strip obtained from normal and MPTP-treated common marmosets (Callithrix jacchus). However, the neurogenic contractions following electrical field stimulation of the intrinsic nerves (EFS) were markedly greater in strips obtained from MPTP treated animals. EFS evoked non-cholinergic contractions following atropine were also greater but the contribution of the cholinergic innervation as a proportion of the overall contraction was smaller in the detrusor strips of MPTP treated animals, suggesting a preferential enhancement of the non-cholinergic transmission. Although dopaminergic mechanisms has been proposed to underlie bladder hyperreflexia in MPTP-treated animals with intact bladder, the present data indicates that the increased neurogenically mediated contractions where no extrinsic innervation exists might be due to long-term adaptive changes locally as a result of the loss of the nigrostriatal output.en
dc.format.extent19
dc.language.isoeng
dc.relation.ispartofPLoS ONE
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.titleAltered detrusor contractility in MPTP-treated common marmosets with bladder hyperreflexiaen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionNeurodegenerative Diseases
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionBasic and Clinical Science Unit
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2017-03-31
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1371/journal.pone.0175797
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nd/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record